Sfoglia per Autore
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors
2021-01-01 Campiani, Giuseppe; Cavella, Caterina; Osko, Jeremy D; Brindisi, Margherita; Relitti, Nicola; Brogi, Simone; Saraswati, A Prasanth; Federico, Stefano; Chemi, Giulia; Maramai, Samuele; Carullo, Gabriele; Jaeger, Benedikt; Carleo, Alfonso; Benedetti, Rosaria; Sarno, Federica; Lamponi, Stefania; Rottoli, Paola; Bargagli, Elena; Bertucci, Carlo; Tedesco, Daniele; Herp, Daniel; Senger, Johanna; Ruberti, Giovina; Saccoccia, Fulvio; Saponara, Simona; Gorelli, Beatrice; Valoti, Massimo; Kennedy, Breándan; Sundaramurthi, Husvinee; Butini, Stefania; Jung, Manfred; Roach, Katy M; Altucci, Lucia; Bradding, Peter; Christianson, David W; Gemma, Sandra; Prasse, Antje
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation
2021-01-01 Relitti, N.; Saraswati, A. P.; Chemi, G.; Brindisi, M.; Brogi, S.; Herp, D.; Schmidtkunz, K.; Saccoccia, F.; Ruberti, G.; Ulivieri, C.; Vanni, F.; Sarno, F.; Altucci, L.; Lamponi, S.; Jung, M.; Gemma, S.; Butini, S.; Campiani, G.
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas
2020-01-01 Khan, T.; Relitti, N.; Brindisi, M.; Magnano, S.; Zisterer, D.; Gemma, S.; Butini, S.; Campiani, G.
Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents
2020-01-01 Saccoccia, F.; Brindisi, M.; Gimmelli, R.; Relitti, N.; Guidi, A.; Saraswati, A. P.; Cavella, C.; Brogi, S.; Chemi, G.; Butini, S.; Papoff, G.; Senger, J.; Herp, D.; Jung, M.; Campiani, G.; Gemma, S.; Ruberti, G.
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases
2020-01-01 Brindisi, Margherita; Saraswati, A Prasanth; Brogi, Simone; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe
Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials
2020-01-01 Relitti, Nicola; Saraswati, Akella P; Federico, Stefano; Khan, Tuhina; Brindisi, Margherita; Zisterer, Daniela; Brogi, Simone; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation
2020-01-01 Saraswati, A Prasanth; Relitti, Nicola; Brindisi, Margherita; Osko, Jeremy D; Chemi, Giulia; Federico, Stefano; Grillo, Alessandro; Brogi, Simone; Mccabe, Niamh H; Turkington, Richard C; Ibrahim, Ola; O'Sullivan, Jeffrey; Lamponi, Stefania; Ghanim, Magda; Kelly, Vincent P; Zisterer, Daniela; Amet, Rebecca; Hannon Barroeta, Patricia; Vanni, Francesca; Ulivieri, Cristina; Herp, Daniel; Sarno, Federica; Di Costanzo, Antonella; Saccoccia, Fulvio; Ruberti, Giovina; Jung, Manfred; Altucci, Lucia; Gemma, Sandra; Butini, Stefania; Christianson, David W; Campiani, Giuseppe
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II)
2019-01-01 D'Alessandro, S.; Alfano, G.; Di Cerbo, L.; Brogi, S.; Chemi, G.; Relitti, N.; Brindisi, M.; Lamponi, S.; Novellino, E.; Campiani, G.; Gemma, S.; Basilico, N.; Taramelli, D.; Baratto, M. C.; Pogni, R.; Butini, S.
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision
2019-01-01 Chemi, G.; Brindisi, M.; Brogi, S.; Relitti, N.; Butini, S.; Gemma, S.; Campiani, G.
Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents
2019-01-01 Brindisi, Margherita; Ulivieri, Cristina; Alfano, Gloria; Gemma, Sandra; de Asís Balaguer, Francisco; Khan, Tuhina; Grillo, Alessandro; Chemi, Giulia; Menchon, Grégory; Prota, Andrea E; Olieric, Natacha; Lucena-Agell, Daniel; Barasoain, Isabel; Diaz, J Fernando; Nebbioso, Angela; Conte, Mariarosaria; Lopresti, Ludovica; Magnano, Stefania; Amet, Rebecca; Kinsella, Paula; Zisterer, Daniela M; Ibrahim, Ola; O'Sullivan, Jeff; Morbidelli, Lucia; Spaccapelo, Roberta; Baldari, Cosima; Butini, Stefania; Novellino, Ettore; Campiani, Giuseppe; Altucci, Lucia; Steinmetz, Michel O; Brogi, Simone
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems
2019-01-01 Grillo, A.; Chemi, G.; Brogi, S.; Brindisi, M.; Relitti, N.; Fezza, F.; Fazio, D.; Castelletti, L.; Perdona, E.; Wong, A.; Lamponi, S.; Pecorelli, A.; Benedusi, M.; Fantacci, M.; Valoti, M.; Valacchi, G.; Micheli, F.; Novellino, E.; Campiani, G.; Butini, S.; Maccarrone, M.; Gemma, S.
Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors
2019-01-01 Saraswati, A. P.; Relitti, N.; Brindisi, M.; Gemma, S.; Zisterer, D.; Butini, S.; Campiani, G.
Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure–Activity Relationship Studies
2019-01-01 Ghosh, A. K.; Brindisi, M.; Yen, Y. -C.; Lendy, E. K.; Kovela, S.; Cardenas, E. L.; Reddy, B. S.; Rao, K. V.; Downs, D.; Huang, X.; Tang, J.; Mesecar, A. D.
Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach
2019-01-01 Sirous, Hajar; Chemi, Giulia; Gemma, Sandra; Butini, Stefania; Debyser, Zeger; Christ, Frauke; Saghaie, Lotfollah; Brogi, Simone; Fassihi, Afshin; Campiani, Giuseppe; Brindisi, Margherita
Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders
2019-01-01 Brogi, Simone; Campiani, Giuseppe; Brindisi, Margherita; Butini, Stefania
Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand
2018-01-01 Ghosh, A. K.; Ghosh, K.; Brindisi, M.; Lendy, E. K.; Yen, Y. -C.; Kumaragurubaran, N.; Huang, X.; Tang, J.; Mesecar, A. D.
Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants
2018-01-01 Ghosh, Arun K; Rao, Kalapala Venkateswara; Nyalapatla, Prasanth R; Kovela, Satish; Brindisi, Margherita; Osswald, Heather L; Sekhara Reddy, Bhavanam; Agniswamy, Johnson; Wang, Yuan-Fang; Aoki, Manabu; Hattori, Shin-Ichiro; Weber, Irene T; Mitsuya, Hiroaki
Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis
2018-01-01 Ghosh, A. K.; Nyalapatla, R. P.; Kovela, S.; Rao, K. V.; Brindisi, M.; Osswald, H. L.; Amano, M.; Aoki, M.; Agniswamy, J.; Wang, Y. -F.; Weber, I. T.; Mitsuya, H.
Synthetic studies toward bicyclic endoperoxides presenting polar side chains
2018-01-01 Gemma, Sandra; DI CERBO, Luisa; Relitti, Nicola; Vallone, Alessandra; Brindisi, Margherita; Brogi, Simone; Chemi, Giulia; Novellino, Ettore; Campiani, Giuseppe; Butini, Stefania
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents
2018-01-01 Federico, Stefano; Khan, Tuhina; Relitti, Nicola; Chemi, Giulia; Brindisi, Margherita; Brogi, Simone; Novellino, Ettore; Zisterer, Daniela M.; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors | 1-gen-2021 | Campiani, Giuseppe; Cavella, Caterina; Osko, Jeremy D; Brindisi, Margherita; Relitti, Nicola; Brogi, Simone; Saraswati, A Prasanth; Federico, Stefano; Chemi, Giulia; Maramai, Samuele; Carullo, Gabriele; Jaeger, Benedikt; Carleo, Alfonso; Benedetti, Rosaria; Sarno, Federica; Lamponi, Stefania; Rottoli, Paola; Bargagli, Elena; Bertucci, Carlo; Tedesco, Daniele; Herp, Daniel; Senger, Johanna; Ruberti, Giovina; Saccoccia, Fulvio; Saponara, Simona; Gorelli, Beatrice; Valoti, Massimo; Kennedy, Breándan; Sundaramurthi, Husvinee; Butini, Stefania; Jung, Manfred; Roach, Katy M; Altucci, Lucia; Bradding, Peter; Christianson, David W; Gemma, Sandra; Prasse, Antje | - | |
| Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation | 1-gen-2021 | Relitti, N.; Saraswati, A. P.; Chemi, G.; Brindisi, M.; Brogi, S.; Herp, D.; Schmidtkunz, K.; Saccoccia, F.; Ruberti, G.; Ulivieri, C.; Vanni, F.; Sarno, F.; Altucci, L.; Lamponi, S.; Jung, M.; Gemma, S.; Butini, S.; Campiani, G. | - | |
| Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas | 1-gen-2020 | Khan, T.; Relitti, N.; Brindisi, M.; Magnano, S.; Zisterer, D.; Gemma, S.; Butini, S.; Campiani, G. | - | |
| Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents | 1-gen-2020 | Saccoccia, F.; Brindisi, M.; Gimmelli, R.; Relitti, N.; Guidi, A.; Saraswati, A. P.; Cavella, C.; Brogi, S.; Chemi, G.; Butini, S.; Papoff, G.; Senger, J.; Herp, D.; Jung, M.; Campiani, G.; Gemma, S.; Ruberti, G. | - | |
| Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases | 1-gen-2020 | Brindisi, Margherita; Saraswati, A Prasanth; Brogi, Simone; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe | - | |
| Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials | 1-gen-2020 | Relitti, Nicola; Saraswati, Akella P; Federico, Stefano; Khan, Tuhina; Brindisi, Margherita; Zisterer, Daniela; Brogi, Simone; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe | - | |
| Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation | 1-gen-2020 | Saraswati, A Prasanth; Relitti, Nicola; Brindisi, Margherita; Osko, Jeremy D; Chemi, Giulia; Federico, Stefano; Grillo, Alessandro; Brogi, Simone; Mccabe, Niamh H; Turkington, Richard C; Ibrahim, Ola; O'Sullivan, Jeffrey; Lamponi, Stefania; Ghanim, Magda; Kelly, Vincent P; Zisterer, Daniela; Amet, Rebecca; Hannon Barroeta, Patricia; Vanni, Francesca; Ulivieri, Cristina; Herp, Daniel; Sarno, Federica; Di Costanzo, Antonella; Saccoccia, Fulvio; Ruberti, Giovina; Jung, Manfred; Altucci, Lucia; Gemma, Sandra; Butini, Stefania; Christianson, David W; Campiani, Giuseppe | - | |
| Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) | 1-gen-2019 | D'Alessandro, S.; Alfano, G.; Di Cerbo, L.; Brogi, S.; Chemi, G.; Relitti, N.; Brindisi, M.; Lamponi, S.; Novellino, E.; Campiani, G.; Gemma, S.; Basilico, N.; Taramelli, D.; Baratto, M. C.; Pogni, R.; Butini, S. | - | |
| A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision | 1-gen-2019 | Chemi, G.; Brindisi, M.; Brogi, S.; Relitti, N.; Butini, S.; Gemma, S.; Campiani, G. | - | |
| Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents | 1-gen-2019 | Brindisi, Margherita; Ulivieri, Cristina; Alfano, Gloria; Gemma, Sandra; de Asís Balaguer, Francisco; Khan, Tuhina; Grillo, Alessandro; Chemi, Giulia; Menchon, Grégory; Prota, Andrea E; Olieric, Natacha; Lucena-Agell, Daniel; Barasoain, Isabel; Diaz, J Fernando; Nebbioso, Angela; Conte, Mariarosaria; Lopresti, Ludovica; Magnano, Stefania; Amet, Rebecca; Kinsella, Paula; Zisterer, Daniela M; Ibrahim, Ola; O'Sullivan, Jeff; Morbidelli, Lucia; Spaccapelo, Roberta; Baldari, Cosima; Butini, Stefania; Novellino, Ettore; Campiani, Giuseppe; Altucci, Lucia; Steinmetz, Michel O; Brogi, Simone | - | |
| Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems | 1-gen-2019 | Grillo, A.; Chemi, G.; Brogi, S.; Brindisi, M.; Relitti, N.; Fezza, F.; Fazio, D.; Castelletti, L.; Perdona, E.; Wong, A.; Lamponi, S.; Pecorelli, A.; Benedusi, M.; Fantacci, M.; Valoti, M.; Valacchi, G.; Micheli, F.; Novellino, E.; Campiani, G.; Butini, S.; Maccarrone, M.; Gemma, S. | - | |
| Raising the bar in anticancer therapy: recent advances in, and perspectives on, telomerase inhibitors | 1-gen-2019 | Saraswati, A. P.; Relitti, N.; Brindisi, M.; Gemma, S.; Zisterer, D.; Butini, S.; Campiani, G. | - | |
| Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure–Activity Relationship Studies | 1-gen-2019 | Ghosh, A. K.; Brindisi, M.; Yen, Y. -C.; Lendy, E. K.; Kovela, S.; Cardenas, E. L.; Reddy, B. S.; Rao, K. V.; Downs, D.; Huang, X.; Tang, J.; Mesecar, A. D. | - | |
| Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach | 1-gen-2019 | Sirous, Hajar; Chemi, Giulia; Gemma, Sandra; Butini, Stefania; Debyser, Zeger; Christ, Frauke; Saghaie, Lotfollah; Brogi, Simone; Fassihi, Afshin; Campiani, Giuseppe; Brindisi, Margherita | - | |
| Allosteric Modulation of Ionotropic Glutamate Receptors: An Outlook on New Therapeutic Approaches To Treat Central Nervous System Disorders | 1-gen-2019 | Brogi, Simone; Campiani, Giuseppe; Brindisi, Margherita; Butini, Stefania | - | |
| Design, synthesis, X-ray studies, and biological evaluation of novel BACE1 inhibitors with bicyclic isoxazoline carboxamides as the P3 ligand | 1-gen-2018 | Ghosh, A. K.; Ghosh, K.; Brindisi, M.; Lendy, E. K.; Yen, Y. -C.; Kumaragurubaran, N.; Huang, X.; Tang, J.; Mesecar, A. D. | - | |
| Design of Highly Potent, Dual-Acting and Central-Nervous-System-Penetrating HIV-1 Protease Inhibitors with Excellent Potency against Multidrug-Resistant HIV-1 Variants | 1-gen-2018 | Ghosh, Arun K; Rao, Kalapala Venkateswara; Nyalapatla, Prasanth R; Kovela, Satish; Brindisi, Margherita; Osswald, Heather L; Sekhara Reddy, Bhavanam; Agniswamy, Johnson; Wang, Yuan-Fang; Aoki, Manabu; Hattori, Shin-Ichiro; Weber, Irene T; Mitsuya, Hiroaki | - | |
| Design and Synthesis of Highly Potent HIV-1 Protease Inhibitors Containing Tricyclic Fused Ring Systems as Novel P2 Ligands: Structure-Activity Studies, Biological and X-ray Structural Analysis | 1-gen-2018 | Ghosh, A. K.; Nyalapatla, R. P.; Kovela, S.; Rao, K. V.; Brindisi, M.; Osswald, H. L.; Amano, M.; Aoki, M.; Agniswamy, J.; Wang, Y. -F.; Weber, I. T.; Mitsuya, H. | - | |
| Synthetic studies toward bicyclic endoperoxides presenting polar side chains | 1-gen-2018 | Gemma, Sandra; DI CERBO, Luisa; Relitti, Nicola; Vallone, Alessandra; Brindisi, Margherita; Brogi, Simone; Chemi, Giulia; Novellino, Ettore; Campiani, Giuseppe; Butini, Stefania | - | |
| A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents | 1-gen-2018 | Federico, Stefano; Khan, Tuhina; Relitti, Nicola; Chemi, Giulia; Brindisi, Margherita; Brogi, Simone; Novellino, Ettore; Zisterer, Daniela M.; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania | - |
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