Sfoglia per Autore
Design of 2-Aminobenzothiazole Derivatives Targeting Trypanosomatid PTR1 by a Multidisciplinary Fragment Hybridization Approach
2025-01-01 Panecka-Hofman, Joanna; Linciano, Pasquale; Pöhner, Ina; Dyguda-Kazimierowicz, Edyta; Jedwabny, Wiktoria; Landi, Giacomo; Santarem, Nuno; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Luciani, Rosaria; Ferrari, Stefania; Aiello, Daniele; Mangani, Stefano; Pozzi, Cecilia; Cordeiro-da-Silva, Anabela; Gul, Sheraz; Costi, Maria Paola; Wade, Rebecca C.
Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics
2025-01-01 Scalvini, Laura; Tagliazucchi, Lorenzo; Elisi, Gian Marco; Zappaterra, Dana; Moschella, Maria Gaetana; Fantini, Sebastian; Aiello, Daniele; Guerrini, Remo; Albanese, Valentina; Pacifico, Salvatore; Lopresti, Ludovica; Malpezzi, Giulia; Saporito, Giulia; Ferrari, Stefania; Lamesta, Michele; Losi, Lorena; Pozzi, Cecilia; Mangani, Stefano; Marverti, Gaetano; Venturelli, Alberto; Ponterini, Glauco; D'Arca, Domenico; Mor, Marco; Costi, Maria Paola
Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents
2024-01-01 Francesconi, Valeria; Rizzo, Marco; Pozzi, Cecilia; Tagliazucchi, Lorenzo; Konchie Simo, Claude U.; Saporito, Giulia; Landi, Giacomo; Mangani, Stefano; Carbone, Anna; Schenone, Silvia; Santarém, Nuno; Tavares, Joana; Cordeiro-da-Silva, Anabela; Costi, Maria Paola; Tonelli, Michele
The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents
2024-01-01 Linciano, Pasquale; Pozzi, Cecilia; Tassone, Giusy; Landi, Giacomo; Mangani, Stefano; Santucci, Matteo; Luciani, Rosaria; Ferrari, Stefania; Santarem, Nuno; Tagliazucchi, Lorenzo; Cordeiro-da-Silva, Anabela; Tonelli, Michele; Tondi, Donatella; Bertarini, Laura; Gul, Sheraz; Witt, Gesa; B Moraes, Carolina; Costantino, Luca; Paola Costi, Maria
Metal ion binding to human Glutaminyl Cyclase: a structural perspective
2024-01-01 Tassone, Giusy; Pozzi, Cecilia; Mangani, Stefano
Copper Binding and Redox Activity of α-Synuclein in Membrane-Like Environment
2023-01-01 Bacchella, Chiara; Camponeschi, Francesca; Kolkowska, Paulina; Kola, Arian; Tessari, Isabella; Baratto, Maria Camilla; Bisaglia, Marco; Monzani, Enrico; Bubacco, Luigi; Mangani, Stefano; Casella, Luigi; Dell'Acqua, Simone; Valensin, Daniela
Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth
2022-01-01 Costantino, Luca; Ferrari, Stefania; Santucci, Matteo; Salo-Ahen, Outi Mh; Carosati, Emanuele; Franchini, Silvia; Lauriola, Angela; Pozzi, Cecilia; Trande, Matteo; Gozzi, Gaia; Saxena, Puneet; Cannazza, Giuseppe; Losi, Lorena; Cardinale, Daniela; Venturelli, Alberto; Quotadamo, Antonio; Linciano, Pasquale; Tagliazucchi, Lorenzo; Moschella, Maria Gaetana; Guerrini, Remo; Pacifico, Salvatore; Luciani, Rosaria; Genovese, Filippo; Henrich, Stefan; Alboni, Silvia; Santarem, Nuno; Da Silva Cordeiro, Anabela; Giovannetti, Elisa; Peters, Godefridus J; Pinton, Paolo; Rimessi, Alessandro; Cruciani, Gabriele; Stroud, Robert M; Wade, Rebecca C; Mangani, Stefano; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola
Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP+/NADPH and the substrate folic acid
2022-01-01 Dello Iacono, Lucia; Di Pisa, Flavio; Mangani, Stefano
Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates
2022-01-01 Legru, Alice; Verdirosa, Federica; Vo-Hoang, Yen; Tassone, Giusy; Vascon, Filippo; Thomas, Caitlyn A; Sannio, Filomena; Corsica, Giuseppina; Benvenuti, Manuela; Feller, Georges; Coulon, Rémi; Marcoccia, Francesca; Devente, Savannah Rowane; Bouajila, Ezeddine; Piveteau, Catherine; Leroux, Florence; Deprez-Poulain, Rebecca; Deprez, Benoît; Licznar-Fajardo, Patricia; Crowder, Michael W; Cendron, Laura; Pozzi, Cecilia; Mangani, Stefano; Docquier, Jean-Denis; Hernandez, Jean-François; Gavara, Laurent
Structural characterization of human heat shock protein 90 N-Terminal domain and its variants K112R and K112A in complex with a potent 1,2,3-Triazole-based inhibitor
2022-01-01 Tassone, Giusy; Mazzorana, Marco; Mangani, Stefano; Petricci, Elena; Cini, Elena; Giannini, Giuseppe; Pozzi, Cecilia; Maramai, Samuele
Multitarget, selective compound design yields potent inhibitors of a Kinetoplastid Pteridine Reductase 1
2022-01-01 Pöhner, Ina; Quotadamo, Antonio; Panecka-Hofman, Joanna; Luciani, Rosaria; Santucci, Matteo; Linciano, Pasquale; Landi, Giacomo; Di Pisa, Flavio; Dello Iacono, Lucia; Pozzi, Cecilia; Mangani, Stefano; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Santarem, Nuno; Cordeiro-da-Silva, Anabela; Costi, Maria P; Venturelli, Alberto; Wade, Rebecca C
Xanthopsin-like systems via site-specific click-functionalization of a retinoic acid binding protein
2022-01-01 Tassone, G.; Paolino, M.; Pozzi, C.; Reale, A.; Salvini, L.; Giorgi, G.; Orlandini, M.; Galvagni, F.; Mangani, S.; Yang, X.; Carlotti, B.; Ortica, F.; Latterini, L.; Olivucci, M.; Cappelli, A.
1,2,4-Triazole-3-Thione analogues with a 2-Ethylbenzoic acid at position 4 as VIM-type metallo-β-Lactamase inhibitors
2022-01-01 Verdirosa, Federica; Gavara, Laurent; Sevaille, Laurent; Tassone, Giusy; Corsica, Giuseppina; Legru, Alice; Feller, Georges; Chelini, Giulia; Mercuri, Paola Sandra; Tanfoni, Silvia; Sannio, Filomena; Benvenuti, Manuela; Cerboni, Giulia; De Luca, Filomena; Bouajila, Ezeddine; Vo Hoang, Yen; Licznar-Fajardo, Patricia; Galleni, Moreno; Pozzi, Cecilia; Mangani, Stefano; Docquier, Jean-Denis; Hernandez, Jean-François
1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity
2021-01-01 Legru, Alice; Verdirosa, Federica; Hernandez, Jean-François; Tassone, Giusy; Sannio, Filomena; Benvenuti, Manuela; Conde, Pierre-Alexis; Bossis, Guillaume; Thomas, Caitlyn A; Crowder, Michael W; Dillenberger, Melissa; Becker, Katja; Pozzi, Cecilia; Mangani, Stefano; Docquier, Jean-Denis; Gavara, Laurent
Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases
2021-01-01 Santucci, Matteo; Luciani, Rosaria; Gianquinto, Eleonora; Pozzi, Cecilia; Pisa, Flavio di; Dello Iacono, Lucia; Landi, Giacomo; Tagliazucchi, Lorenzo; Mangani, Stefano; Spyrakis, Francesca; Costi, Maria Paola
Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations
2021-01-01 Pozzi, Cecilia; Santucci, Matteo; Marverti, Gaetano; D'Arca, Domenico; Tagliazucchi, Lorenzo; Ferrari, Stefania; Gozzi, Gaia; Losi, Lorena; Tassone, Giusy; Mangani, Stefano; Ponterini, Glauco; Costi, Maria Paola
Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase
2021-01-01 Tassone, Giusy; Landi, Giacomo; Linciano, Pasquale; Francesconi, Valeria; Tonelli, Michele; Tagliazucchi, Lorenzo; Costi, Maria Paola; Mangani, Stefano; Pozzi, Cecilia
Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin
2021-01-01 Ciambellotti, Silvia; Pratesi, Alessandro; Tassone, Giusy; Turano, Paola; Mangani, Stefano; Pozzi, Cecilia
ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-Producing enterobacteriaceae
2020-01-01 Davies, D. T.; Leiris, S.; Sprynski, N.; Castandet, J.; Lozano, C.; Bousquet, J.; Zalacain, M.; Vasa, S.; Dasari, P. K.; Pattipati, R.; Vempala, N.; Gujjewar, S.; Godi, S.; Jallala, R.; Sathyap, R. R.; Darshanoju, N. A.; Ravu, V. R.; Juventhala, R. R.; Pottabathini, N.; Sharma, S.; Pothukanuri, S.; Holden, K.; Warn, P.; Marcoccia, F.; Benvenuti, M.; Pozzi, C.; Mangani, S.; Docquier, J. D.; Lemonnier, M.; Everett, M.
Discovery of ANT3310, a novel broad-spectrum serine β-Lactamase inhibitor of the diazabicyclooctane class, which strongly potentiates meropenem activity against carbapenem-resistant enterobacterales and acinetobacter baumannii
2020-01-01 Davies, D. T.; Leiris, S.; Zalacain, M.; Sprynski, N.; Castandet, J.; Bousquet, J.; Lozano, C.; Llanos, A.; Alibaud, L.; Vasa, S.; Pattipati, R.; Valige, R.; Kummari, B.; Pothukanuri, S.; De Piano, C.; Morrissey, I.; Holden, K.; Warn, P.; Marcoccia, F.; Benvenuti, M.; Pozzi, C.; Tassone, G.; Mangani, S.; Docquier, J. D.; Pallin, D.; Elliot, R.; Lemonnier, M.; Everett, M.
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| Design of 2-Aminobenzothiazole Derivatives Targeting Trypanosomatid PTR1 by a Multidisciplinary Fragment Hybridization Approach | 1-gen-2025 | Panecka-Hofman, Joanna; Linciano, Pasquale; Pöhner, Ina; Dyguda-Kazimierowicz, Edyta; Jedwabny, Wiktoria; Landi, Giacomo; Santarem, Nuno; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Luciani, Rosaria; Ferrari, Stefania; Aiello, Daniele; Mangani, Stefano; Pozzi, Cecilia; Cordeiro-da-Silva, Anabela; Gul, Sheraz; Costi, Maria Paola; Wade, Rebecca C. | - | |
| Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics | 1-gen-2025 | Scalvini, Laura; Tagliazucchi, Lorenzo; Elisi, Gian Marco; Zappaterra, Dana; Moschella, Maria Gaetana; Fantini, Sebastian; Aiello, Daniele; Guerrini, Remo; Albanese, Valentina; Pacifico, Salvatore; Lopresti, Ludovica; Malpezzi, Giulia; Saporito, Giulia; Ferrari, Stefania; Lamesta, Michele; Losi, Lorena; Pozzi, Cecilia; Mangani, Stefano; Marverti, Gaetano; Venturelli, Alberto; Ponterini, Glauco; D'Arca, Domenico; Mor, Marco; Costi, Maria Paola | - | |
| Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents | 1-gen-2024 | Francesconi, Valeria; Rizzo, Marco; Pozzi, Cecilia; Tagliazucchi, Lorenzo; Konchie Simo, Claude U.; Saporito, Giulia; Landi, Giacomo; Mangani, Stefano; Carbone, Anna; Schenone, Silvia; Santarém, Nuno; Tavares, Joana; Cordeiro-da-Silva, Anabela; Costi, Maria Paola; Tonelli, Michele | - | |
| The discovery of aryl-2-nitroethyl triamino pyrimidines as anti-Trypanosoma brucei agents | 1-gen-2024 | Linciano, Pasquale; Pozzi, Cecilia; Tassone, Giusy; Landi, Giacomo; Mangani, Stefano; Santucci, Matteo; Luciani, Rosaria; Ferrari, Stefania; Santarem, Nuno; Tagliazucchi, Lorenzo; Cordeiro-da-Silva, Anabela; Tonelli, Michele; Tondi, Donatella; Bertarini, Laura; Gul, Sheraz; Witt, Gesa; B Moraes, Carolina; Costantino, Luca; Paola Costi, Maria | - | |
| Metal ion binding to human Glutaminyl Cyclase: a structural perspective | 1-gen-2024 | Tassone, Giusy; Pozzi, Cecilia; Mangani, Stefano | - | |
| Copper Binding and Redox Activity of α-Synuclein in Membrane-Like Environment | 1-gen-2023 | Bacchella, Chiara; Camponeschi, Francesca; Kolkowska, Paulina; Kola, Arian; Tessari, Isabella; Baratto, Maria Camilla; Bisaglia, Marco; Monzani, Enrico; Bubacco, Luigi; Mangani, Stefano; Casella, Luigi; Dell'Acqua, Simone; Valensin, Daniela | - | |
| Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth | 1-gen-2022 | Costantino, Luca; Ferrari, Stefania; Santucci, Matteo; Salo-Ahen, Outi Mh; Carosati, Emanuele; Franchini, Silvia; Lauriola, Angela; Pozzi, Cecilia; Trande, Matteo; Gozzi, Gaia; Saxena, Puneet; Cannazza, Giuseppe; Losi, Lorena; Cardinale, Daniela; Venturelli, Alberto; Quotadamo, Antonio; Linciano, Pasquale; Tagliazucchi, Lorenzo; Moschella, Maria Gaetana; Guerrini, Remo; Pacifico, Salvatore; Luciani, Rosaria; Genovese, Filippo; Henrich, Stefan; Alboni, Silvia; Santarem, Nuno; Da Silva Cordeiro, Anabela; Giovannetti, Elisa; Peters, Godefridus J; Pinton, Paolo; Rimessi, Alessandro; Cruciani, Gabriele; Stroud, Robert M; Wade, Rebecca C; Mangani, Stefano; Marverti, Gaetano; D'Arca, Domenico; Ponterini, Glauco; Costi, Maria Paola | - | |
| Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP+/NADPH and the substrate folic acid | 1-gen-2022 | Dello Iacono, Lucia; Di Pisa, Flavio; Mangani, Stefano | - | |
| Optimization of 1,2,4-Triazole-3-thiones toward Broad-Spectrum Metallo-β-lactamase Inhibitors Showing Potent Synergistic Activity on VIM- and NDM-1-Producing Clinical Isolates | 1-gen-2022 | Legru, Alice; Verdirosa, Federica; Vo-Hoang, Yen; Tassone, Giusy; Vascon, Filippo; Thomas, Caitlyn A; Sannio, Filomena; Corsica, Giuseppina; Benvenuti, Manuela; Feller, Georges; Coulon, Rémi; Marcoccia, Francesca; Devente, Savannah Rowane; Bouajila, Ezeddine; Piveteau, Catherine; Leroux, Florence; Deprez-Poulain, Rebecca; Deprez, Benoît; Licznar-Fajardo, Patricia; Crowder, Michael W; Cendron, Laura; Pozzi, Cecilia; Mangani, Stefano; Docquier, Jean-Denis; Hernandez, Jean-François; Gavara, Laurent | - | |
| Structural characterization of human heat shock protein 90 N-Terminal domain and its variants K112R and K112A in complex with a potent 1,2,3-Triazole-based inhibitor | 1-gen-2022 | Tassone, Giusy; Mazzorana, Marco; Mangani, Stefano; Petricci, Elena; Cini, Elena; Giannini, Giuseppe; Pozzi, Cecilia; Maramai, Samuele | - | |
| Multitarget, selective compound design yields potent inhibitors of a Kinetoplastid Pteridine Reductase 1 | 1-gen-2022 | Pöhner, Ina; Quotadamo, Antonio; Panecka-Hofman, Joanna; Luciani, Rosaria; Santucci, Matteo; Linciano, Pasquale; Landi, Giacomo; Di Pisa, Flavio; Dello Iacono, Lucia; Pozzi, Cecilia; Mangani, Stefano; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Santarem, Nuno; Cordeiro-da-Silva, Anabela; Costi, Maria P; Venturelli, Alberto; Wade, Rebecca C | - | |
| Xanthopsin-like systems via site-specific click-functionalization of a retinoic acid binding protein | 1-gen-2022 | Tassone, G.; Paolino, M.; Pozzi, C.; Reale, A.; Salvini, L.; Giorgi, G.; Orlandini, M.; Galvagni, F.; Mangani, S.; Yang, X.; Carlotti, B.; Ortica, F.; Latterini, L.; Olivucci, M.; Cappelli, A. | - | |
| 1,2,4-Triazole-3-Thione analogues with a 2-Ethylbenzoic acid at position 4 as VIM-type metallo-β-Lactamase inhibitors | 1-gen-2022 | Verdirosa, Federica; Gavara, Laurent; Sevaille, Laurent; Tassone, Giusy; Corsica, Giuseppina; Legru, Alice; Feller, Georges; Chelini, Giulia; Mercuri, Paola Sandra; Tanfoni, Silvia; Sannio, Filomena; Benvenuti, Manuela; Cerboni, Giulia; De Luca, Filomena; Bouajila, Ezeddine; Vo Hoang, Yen; Licznar-Fajardo, Patricia; Galleni, Moreno; Pozzi, Cecilia; Mangani, Stefano; Docquier, Jean-Denis; Hernandez, Jean-François | - | |
| 1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-β-lactamase inhibitors with re-sensitization activity | 1-gen-2021 | Legru, Alice; Verdirosa, Federica; Hernandez, Jean-François; Tassone, Giusy; Sannio, Filomena; Benvenuti, Manuela; Conde, Pierre-Alexis; Bossis, Guillaume; Thomas, Caitlyn A; Crowder, Michael W; Dillenberger, Melissa; Becker, Katja; Pozzi, Cecilia; Mangani, Stefano; Docquier, Jean-Denis; Gavara, Laurent | - | |
| Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases | 1-gen-2021 | Santucci, Matteo; Luciani, Rosaria; Gianquinto, Eleonora; Pozzi, Cecilia; Pisa, Flavio di; Dello Iacono, Lucia; Landi, Giacomo; Tagliazucchi, Lorenzo; Mangani, Stefano; Spyrakis, Francesca; Costi, Maria Paola | - | |
| Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations | 1-gen-2021 | Pozzi, Cecilia; Santucci, Matteo; Marverti, Gaetano; D'Arca, Domenico; Tagliazucchi, Lorenzo; Ferrari, Stefania; Gozzi, Gaia; Losi, Lorena; Tassone, Giusy; Mangani, Stefano; Ponterini, Glauco; Costi, Maria Paola | - | |
| Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase | 1-gen-2021 | Tassone, Giusy; Landi, Giacomo; Linciano, Pasquale; Francesconi, Valeria; Tonelli, Michele; Tagliazucchi, Lorenzo; Costi, Maria Paola; Mangani, Stefano; Pozzi, Cecilia | - | |
| Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin | 1-gen-2021 | Ciambellotti, Silvia; Pratesi, Alessandro; Tassone, Giusy; Turano, Paola; Mangani, Stefano; Pozzi, Cecilia | - | |
| ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of infections caused by NDM-Producing enterobacteriaceae | 1-gen-2020 | Davies, D. T.; Leiris, S.; Sprynski, N.; Castandet, J.; Lozano, C.; Bousquet, J.; Zalacain, M.; Vasa, S.; Dasari, P. K.; Pattipati, R.; Vempala, N.; Gujjewar, S.; Godi, S.; Jallala, R.; Sathyap, R. R.; Darshanoju, N. A.; Ravu, V. R.; Juventhala, R. R.; Pottabathini, N.; Sharma, S.; Pothukanuri, S.; Holden, K.; Warn, P.; Marcoccia, F.; Benvenuti, M.; Pozzi, C.; Mangani, S.; Docquier, J. D.; Lemonnier, M.; Everett, M. | - | |
| Discovery of ANT3310, a novel broad-spectrum serine β-Lactamase inhibitor of the diazabicyclooctane class, which strongly potentiates meropenem activity against carbapenem-resistant enterobacterales and acinetobacter baumannii | 1-gen-2020 | Davies, D. T.; Leiris, S.; Zalacain, M.; Sprynski, N.; Castandet, J.; Bousquet, J.; Lozano, C.; Llanos, A.; Alibaud, L.; Vasa, S.; Pattipati, R.; Valige, R.; Kummari, B.; Pothukanuri, S.; De Piano, C.; Morrissey, I.; Holden, K.; Warn, P.; Marcoccia, F.; Benvenuti, M.; Pozzi, C.; Tassone, G.; Mangani, S.; Docquier, J. D.; Pallin, D.; Elliot, R.; Lemonnier, M.; Everett, M. | - |
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