Anti-idiotypic antibodies which recognise the idiotope of an antibody specific for a yeast killer toxin possess microbicidal activity. Fragments (e.g. decapeptides) of these anti-idiotypic antibodies, particularly those comprising CDR residues, also show microbicidal activity, as do peptides having 5 the same sequence but composed of D-amino acids, or including amino acid substitutions. Peptidomimetics of these microbicidal polypeptides are also provided. Antiviral activity is also seen.
Luciano, P., Antonio, C., Bracci, L., Neri, P., Lozzi, L. (2003)Toxin-related antibodies with antimicrobial and antiviral activity. . Brevetto No. US 7722876 B2.
Toxin-related antibodies with antimicrobial and antiviral activity
BRACCI, LUISA;NERI, PAOLO;LOZZI, LUISA
2003-01-01
Abstract
Anti-idiotypic antibodies which recognise the idiotope of an antibody specific for a yeast killer toxin possess microbicidal activity. Fragments (e.g. decapeptides) of these anti-idiotypic antibodies, particularly those comprising CDR residues, also show microbicidal activity, as do peptides having 5 the same sequence but composed of D-amino acids, or including amino acid substitutions. Peptidomimetics of these microbicidal polypeptides are also provided. Antiviral activity is also seen.
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https://hdl.handle.net/11365/996223
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