In vivo NMR spectroscopy and sugars selectively enriched with C-13 were used to follow the step-by-step metabolic kinetics of microorganisms. A new modelling approach is discussed for the analysis of microbial dynamics. It is based on structurally non linear compartmental models and on the dynamics of the substrate and product. This combined approach was tested with the fermentation of sugars by bacteria and yeasts. The models were fitted with experimental data to obtain the values of the kinetic constants related to the investigated metabolic path.
Bastianoni, S., Bonechi, C., Gastaldelli, A., Martini, S., Rossi, C. (2000). Modelling interpretation of the kinetics of metabolic processes. In Chemistry at the Beginning of the Third Millennium. Molecular Design, Supramolecules, Nanotechnology and Beyond (pp. 305-328). BERLIN HEIDELBERG : Springer Verlag.
Modelling interpretation of the kinetics of metabolic processes
BASTIANONI, S.;BONECHI, C.;MARTINI, S.;ROSSI, C.
2000-01-01
Abstract
In vivo NMR spectroscopy and sugars selectively enriched with C-13 were used to follow the step-by-step metabolic kinetics of microorganisms. A new modelling approach is discussed for the analysis of microbial dynamics. It is based on structurally non linear compartmental models and on the dynamics of the substrate and product. This combined approach was tested with the fermentation of sugars by bacteria and yeasts. The models were fitted with experimental data to obtain the values of the kinetic constants related to the investigated metabolic path.
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https://hdl.handle.net/11365/3655
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