The instant invention refers to an antibacterial peptide with all aminoacids in D-configuration, possessing strong antimicrobial activity against Gram-negative and Gram-positive bacteria and Candida strains. The peptide can be in linear form or multimerised on a skeleton of polyacrylamide, of dextrane units or on a skeleton of ethylene glycol units. The peptide is resistant to proteolysis especially when synthesized in the tetra-branched form where identical peptide sequences are linked together by an appropriate molecular scaffold.

Pini, A., Bracci, L., Falciani, C. (2010)Antimicrobial peptide, branched forms thereof, and their use in the treatment of bacterial infections. . Brevetto No. WO2012010266.

Antimicrobial peptide, branched forms thereof, and their use in the treatment of bacterial infections

PINI, ALESSANDRO;BRACCI, LUISA;FALCIANI, CHIARA
2010-01-01

Abstract

The instant invention refers to an antibacterial peptide with all aminoacids in D-configuration, possessing strong antimicrobial activity against Gram-negative and Gram-positive bacteria and Candida strains. The peptide can be in linear form or multimerised on a skeleton of polyacrylamide, of dextrane units or on a skeleton of ethylene glycol units. The peptide is resistant to proteolysis especially when synthesized in the tetra-branched form where identical peptide sequences are linked together by an appropriate molecular scaffold.
Pini, A., Bracci, L., Falciani, C. (2010)Antimicrobial peptide, branched forms thereof, and their use in the treatment of bacterial infections. . Brevetto No. WO2012010266.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/3472
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