The instant invention refers to an antibacterial peptide with all aminoacids in D-configuration, possessing strong antimicrobial activity against Gram-negative and Gram-positive bacteria and Candida strains. The peptide can be in linear form or multimerised on a skeleton of polyacrylamide, of dextrane units or on a skeleton of ethylene glycol units. The peptide is resistant to proteolysis especially when synthesized in the tetra-branched form where identical peptide sequences are linked together by an appropriate molecular scaffold.

Pini, A., Bracci, L., & Falciani, C. (2010)Antimicrobial peptide, branched forms thereof, and their use in the treatment of bacterial infections. . Brevetto No. WO2012010266.

Antimicrobial peptide, branched forms thereof, and their use in the treatment of bacterial infections

PINI, ALESSANDRO;BRACCI, LUISA;FALCIANI, CHIARA
2010

Abstract

The instant invention refers to an antibacterial peptide with all aminoacids in D-configuration, possessing strong antimicrobial activity against Gram-negative and Gram-positive bacteria and Candida strains. The peptide can be in linear form or multimerised on a skeleton of polyacrylamide, of dextrane units or on a skeleton of ethylene glycol units. The peptide is resistant to proteolysis especially when synthesized in the tetra-branched form where identical peptide sequences are linked together by an appropriate molecular scaffold.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11365/3472
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