A procedure for the prepn. of ezetimibe (I) and its new intermediate II is described. The procedure for the prepn. of I comprises: (i) Grignard reaction of amide III [R1, R2, independently, = C1-4-alkyl] with (4-fluorophenyl)magnesium bromide in an org. solvent; and, (ii) stereoselective redn. of the ketone function in II and successive deprotection of the hydroxyl group.

Allegrini, P., Naldini, D., Razzetti, G., Taddei, M. (2007)Procedure for the preparation of ezetimibe. Brevetto No. IT 2007-MI2013.

Procedure for the preparation of ezetimibe

TADDEI, MAURIZIO
2007-01-01

Abstract

A procedure for the prepn. of ezetimibe (I) and its new intermediate II is described. The procedure for the prepn. of I comprises: (i) Grignard reaction of amide III [R1, R2, independently, = C1-4-alkyl] with (4-fluorophenyl)magnesium bromide in an org. solvent; and, (ii) stereoselective redn. of the ketone function in II and successive deprotection of the hydroxyl group.
2007
Allegrini, P., Naldini, D., Razzetti, G., Taddei, M. (2007)Procedure for the preparation of ezetimibe. Brevetto No. IT 2007-MI2013.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/33945
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo