The invention relates to ligand complexes characterised by the presence of a piperazineNONOate residue with metal cations where the cations derive from a transition metal or zinc in a stable oxidation state. These complexes are nitric oxide donors and exert an endothelio-protective effect on the coronary district and stimulate reendothelialization and angiogenesis processes. The invention comprises a preparation process and the therapeutic use of said compounds.
L., C., Ziche, M. (2002)NITRIC OXIDE DONORS BASED ON METALLIC CENTRES. . Brevetto No. EP 1370544 B1.
NITRIC OXIDE DONORS BASED ON METALLIC CENTRES
ZICHE, MARINA
2002-01-01
Abstract
The invention relates to ligand complexes characterised by the presence of a piperazineNONOate residue with metal cations where the cations derive from a transition metal or zinc in a stable oxidation state. These complexes are nitric oxide donors and exert an endothelio-protective effect on the coronary district and stimulate reendothelialization and angiogenesis processes. The invention comprises a preparation process and the therapeutic use of said compounds.
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https://hdl.handle.net/11365/32236
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