The invention relates to ligand complexes characterised by the presence of a piperazineNONOate residue with metal cations where the cations derive from a transition metal or zinc in a stable oxidation state. These complexes are nitric oxide donors and exert an endothelio-protective effect on the coronary district and stimulate reendothelialization and angiogenesis processes. The invention comprises a preparation process and the therapeutic use of said compounds.
L., C., Ziche, M. (2002)NITRIC OXIDE DONORS BASED ON METALLIC CENTRES. Brevetto No. EP 1370544 B1.
NITRIC OXIDE DONORS BASED ON METALLIC CENTRES
ZICHE, MARINA
2002-01-01
Abstract
The invention relates to ligand complexes characterised by the presence of a piperazineNONOate residue with metal cations where the cations derive from a transition metal or zinc in a stable oxidation state. These complexes are nitric oxide donors and exert an endothelio-protective effect on the coronary district and stimulate reendothelialization and angiogenesis processes. The invention comprises a preparation process and the therapeutic use of said compounds.
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https://hdl.handle.net/11365/32236
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