The working hypothesis that lung collagen breakdown products derived from elastase digestion (CDP) up-regulates lung collagen mass is actively pursued in our labaratory. The data reported demonstrate that CDP can stimulate "in vivo" lung collagen synthesis and deposition in alveolar septa. This effect is dose-related and specific to the lung alone.
Calzoni, P., Cavarra, E., Marcolongo, P., Solito, R., Viti, A., Pacini, A., et al. (1992). Regulation of lung collagen synthesis and deposition by collagen breakdown products. In Biology and Pathology of Cell-Matrix Interactions (pp. 21-31). Padova : Cleup Editrice.
Regulation of lung collagen synthesis and deposition by collagen breakdown products
CAVARRA, ELEONORA;MARCOLONGO, PAOLA;SOLITO, RAFFAELLA;TORRICELLI, CLAUDIA;GARDI, CONCETTA;LUNGARELLA, GIUSEPPE
1992-01-01
Abstract
The working hypothesis that lung collagen breakdown products derived from elastase digestion (CDP) up-regulates lung collagen mass is actively pursued in our labaratory. The data reported demonstrate that CDP can stimulate "in vivo" lung collagen synthesis and deposition in alveolar septa. This effect is dose-related and specific to the lung alone.
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https://hdl.handle.net/11365/22162
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