Cytotoxin is one of the candidate factors of virulence of Helicobacter pylori (HP) [1]. Toxigenicity occurs frequently in strains isolated from patients with peptic ulceration [2], and there is serological evidence that cytotoxin production also occurs in vivo. In fact, in immunoblotting tests we saw that all the 31 individuals infected by cytotoxic (CT+) HP strains tested and 14 of 20 patients (70%) infected by noncytotoxic (CT−) organisms had serum immunoglobulin G (IgG) which recognized HP cytotoxin-associated proteins (CAP). IgA to CAP were hardly detected, mostly in patients infected by CT+ strains, while IgM were not detected at all (N. Figura et al., in preparation).
Figura, N., Fanti, O., Guglielmetti, P., Barberi, A., Rossolini, A., Cusi, M.G., et al. (1990). Serum Antibodies to the Vacuolating Toxin Produced by Helicobacter pylori. In Helicobacter pylori, Gastritis and Peptic Ulcer (pp. 159-161). BERLIN HEIDELBERG : Springer-Verlag.
Serum Antibodies to the Vacuolating Toxin Produced by Helicobacter pylori
FIGURA N.;CUSI M. G.;
1990-01-01
Abstract
Cytotoxin is one of the candidate factors of virulence of Helicobacter pylori (HP) [1]. Toxigenicity occurs frequently in strains isolated from patients with peptic ulceration [2], and there is serological evidence that cytotoxin production also occurs in vivo. In fact, in immunoblotting tests we saw that all the 31 individuals infected by cytotoxic (CT+) HP strains tested and 14 of 20 patients (70%) infected by noncytotoxic (CT−) organisms had serum immunoglobulin G (IgG) which recognized HP cytotoxin-associated proteins (CAP). IgA to CAP were hardly detected, mostly in patients infected by CT+ strains, while IgM were not detected at all (N. Figura et al., in preparation).
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/14974
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo