8 Tesi di dottorato

8 Tesi di dottorato: [1009] Home page macrotipologia

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8.1 Tesi Dottorato 1009

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Development and validation of an mRNA vaccine platform expressing the receptor binding domain of the SARS-CoV-2 spike protein or the enhanced green fluorescent protein.

In this thesis the development of an mRNA vaccine platform and its validation are described. The possibilities offered by mRNA vaccines platform are promising, due to their versatility, efficacy and rapid production. In Chapter 3 the production of an mRNA vaccine encoding as an antigen the SARS-CoV-2 Receptor Binding Domain (RBD) of the spike protein is described. mRNA was in vitro transcribed from a DNA template containing all the essential elements for the production of synthetic mRNA, and ...

Audiological characterization of X-linked mouse model

Alport Syndrome (AS) is a group of hereditary diseases caused by mutations in COL4A3, COL4A4, COL4A5 genes, these codify for polypeptidic chains of collagen type IV (respectively alpha3. alpha 4. alpha 5- a345), this network results the major collagenous constituent of the mature mammalian basement membrane (BM) of kidney (renal glomerulus), inner ear and eye. The molecular defect includes the synthesis, assembly, deposition, or function of the alpha3. alpha 4. alpha 5. The diagnosis of AS ...

impact of digital dentistry in daily prosthodontics

The goal of this Ph D thesis was to evaluate the impact of new digital technologies in the field of prosthodontics and to assess the advantages and disadvantages of them through in vivo and in vitro studies to implement their use in everyday practice. Firstly, in vitro studies for fixed and removable prosthodontics were conducted to test the devices and materials in laboratory without variables and potential confounding factors present in whole organisms and to evaluate parameters before tes...

Drought and the olive tree in a changing climate: a multi-level response characterisation to explore and valorise Italian cultivars

The Mediterranean climate faces significant warming and reduced rainfall due to climate change. This will make droughts more frequent and severe, affecting agriculture. Higher temperatures can damage crops while lower rainfall increases the need for irrigation. Despite that irrigation has sustained agriculture in arid regions, competition for water is increasing. To adapt to current challenges, improvements in irrigation practices, adoption of agro-ecological techniques and use of drought-tol...

MAGIC Observations of the Blazar TON 116 in a Multi-wavelength Context

This thesis focuses on the long-standing discussion on the blazar sequence intriguing the astrophysical community since the end of the '90s. Blazars constitute a subclass of Active Galactic Nuclei (AGNs) with a powerful radio jet pointing towards the Earth. They are characterized by a double-peaked Spectral Energy Distribution (SED), whose low-energy bump is thought to be due to synchrotron emission of electrons streaming in the jet, while the high-energy hump is likely due to inverse-Compto...

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