Intraocular tumors may leave the globe through vascular, neural, and transscleral routes and invade the periocular tissues and the orbit. These tumors primarily include retinoblastoma, uveal melanoma, and, to a lesser extent, malignant medulloepithelioma, retinal pigment epithelium carcinoma, and optic disk melanocytoma. The secondary involvement of orbital soft tissues with malignant ocular tumors is a rare condition, and the only clinically significant lesions in this group are the retinoblastoma and choroidal melanoma; therefore, only these tumors are discussed in this chapter.
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