New data on fractal analysis of the bone marrow in myelodysplastic syndromes are recently arising in order to perform differential diagnosis and prognosis in those diseases. Here we report the use of Entropy, or Information Dimension, to evaluate bone marrow biopsies in healthy subjects, in refractory anemia, in refractory anemia with excess blasts (-1 & -2) and in acute myeloid leukemia. Entropy is statistically increased in the patients compared with the normal condition (p < 0.01). Interestingly, entropy increases with the severity of the lesions (p < 0.01). Evaluation of Entropy of the histologic images appears to be able to add objective information relating to the differential diagnosis in myelodysplastic syndromes.
Bianciardi, G., Luzi, P. (2016). Entropy Evaluation of Bone Marrow Biopsies in Myelodysplastic Syndromes. In Deanna Rodgers Editor (a cura di), MYELODYSPLASTIC SYNDROMES (MDS). RISK FACTORS, TREATMENT AND PROGNOSIS (pp. 243-252). New York : Nova Science Publishers, Inc..
Entropy Evaluation of Bone Marrow Biopsies in Myelodysplastic Syndromes
BIANCIARDI, GIORGIO;LUZI, PIETRO
2016-01-01
Abstract
New data on fractal analysis of the bone marrow in myelodysplastic syndromes are recently arising in order to perform differential diagnosis and prognosis in those diseases. Here we report the use of Entropy, or Information Dimension, to evaluate bone marrow biopsies in healthy subjects, in refractory anemia, in refractory anemia with excess blasts (-1 & -2) and in acute myeloid leukemia. Entropy is statistically increased in the patients compared with the normal condition (p < 0.01). Interestingly, entropy increases with the severity of the lesions (p < 0.01). Evaluation of Entropy of the histologic images appears to be able to add objective information relating to the differential diagnosis in myelodysplastic syndromes.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/1000487
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