CHEMI, GIULIA
CHEMI, GIULIA
Dipartimento di Biotecnologie, Chimica e Farmacia
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation
2018-01-01 Brogi, Simone; Brindisi, Margherita; Butini, Stefania; Kshirsagar, Giridhar U.; Maramai, Samuele; Chemi, Giulia; Gemma, Sandra; Campiani, Giuseppe; Novellino, Ettore; Fiorenzani, Paolo; Pinassi, Jessica; Aloisi, Anna Maria; Gynther, Mikko; Venskutonytė, Raminta; Han, Liwei; Frydenvang, Karla; Kastrup, Jette Sandholm; Pickering, Darryl S.
A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents
2018-01-01 Federico, Stefano; Khan, Tuhina; Relitti, Nicola; Chemi, Giulia; Brindisi, Margherita; Brogi, Simone; Novellino, Ettore; Zisterer, Daniela M.; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania
A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision
2019-01-01 Chemi, G.; Brindisi, M.; Brogi, S.; Relitti, N.; Butini, S.; Gemma, S.; Campiani, G.
A repurposing approach for uncovering the anti-tubercular activity of FDA-approved drugs with Potential Multi-Targeting Profiles
2019-01-01 Battah, B.; Chemi, G.; Butini, S.; Campiani, G.; Brogi, S.; Delogu, G.; Gemma, S.
Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation
2017-01-01 Brogi, Simone; Maramai, Samuele; Brindisi, Margherita; Chemi, Giulia; Porcari, Valentina; Corallo, Claudio; Gennari, Luigi; Novellino, Ettore; Ramunno, Anna; Butini, Stefania; Campiani, Giuseppe; Gemma, Sandra
Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues
2018-01-01 Vallone, Alessandra; D'Alessandro, Sarah; Brogi, Simone; Brindisi, Margherita; Chemi, Giulia; Alfano, Gloria; Lamponi, Stefania; Lee, Soon Goo; Jez, Joseph M.; Koolen, Karin J. M.; Dechering, Koen J.; Saponara, Simona; Fusi, Fabio; Gorelli, Beatrice; Taramelli, Donatella; Parapini, Silvia; Caldelari, Reto; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania
Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II)
2019-01-01 D'Alessandro, S.; Alfano, G.; Di Cerbo, L.; Brogi, S.; Chemi, G.; Relitti, N.; Brindisi, M.; Lamponi, S.; Novellino, E.; Campiani, G.; Gemma, S.; Basilico, N.; Taramelli, D.; Baratto, M. C.; Pogni, R.; Butini, S.
Cinnamides Target Leishmania amazonensis Arginase Selectively
2020-01-01 da Silva, Edson Roberto; Come, Júlio Abel Alfredo dos Santos Simone; Brogi, Simone; Calderone, Vincenzo; Chemi, Giulia; Campiani, Giuseppe; Oliveira, Trícia Maria Ferrreira de Sousa; Pham, Thanh-Nhat; Pudlo, Marc; Girard, Corine; Maquiaveli, Claudia do Carmo
Computational tool for fast in silico evaluation of hERG K+ channel affinity
2017-01-01 Chemi, Giulia; Gemma, Sandra; Campiani, Giuseppe; Brogi, Simone; Butini, Stefania; Brindisi, Margherita
Computer-aided drug discovery methodologies for the identification and optimization of bioactive compounds
2020-01-01 Chemi, Giulia
Computer-driven development of an in silico tool for finding selective histone deacetylase 1 inhibitors
2020-01-01 Sirous, H.; Campiani, G.; Brogi, S.; Calderone, V.; Chemi, G.
Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents
2020-01-01 Di Capua, Angela; Reale, Annalisa; Paolino, Marco; Chemi, Giulia; Brogi, Simone; Cappelli, Andrea; Giorgi, Gianluca; Grande, Fedora; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Matucci, Rosanna; Garofalo, Antonio; Anzini, Maurizio
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems
2019-01-01 Grillo, A.; Chemi, G.; Brogi, S.; Brindisi, M.; Relitti, N.; Fezza, F.; Fazio, D.; Castelletti, L.; Perdona, E.; Wong, A.; Lamponi, S.; Pecorelli, A.; Benedusi, M.; Fantacci, M.; Valoti, M.; Valacchi, G.; Micheli, F.; Novellino, E.; Campiani, G.; Butini, S.; Maccarrone, M.; Gemma, S.
First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents
2017-01-01 Brogi, Simone; Ramunno, Anna; Savi, Lida; Chemi, Giulia; Alfano, Gloria; Pecorelli, Alessandra; Pambianchi, Erika; Galatello, Paola; Compagnoni, Giulia; Focher, Federico; Biamonti, Giuseppe; Valacchi, Giuseppe; Butini, Stefania; Gemma, Sandra; Campiani, Giuseppe; Brindisi, Margherita
Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors
2021-01-01 Campiani, Giuseppe; Cavella, Caterina; Osko, Jeremy D; Brindisi, Margherita; Relitti, Nicola; Brogi, Simone; Saraswati, A Prasanth; Federico, Stefano; Chemi, Giulia; Maramai, Samuele; Carullo, Gabriele; Jaeger, Benedikt; Carleo, Alfonso; Benedetti, Rosaria; Sarno, Federica; Lamponi, Stefania; Rottoli, Paola; Bargagli, Elena; Bertucci, Carlo; Tedesco, Daniele; Herp, Daniel; Senger, Johanna; Ruberti, Giovina; Saccoccia, Fulvio; Saponara, Simona; Gorelli, Beatrice; Valoti, Massimo; Kennedy, Breándan; Sundaramurthi, Husvinee; Butini, Stefania; Jung, Manfred; Roach, Katy M; Altucci, Lucia; Bradding, Peter; Christianson, David W; Gemma, Sandra; Prasse, Antje
Identification of novel 3-Hydroxy-pyran-4-one derivatives as potent HIV-1 integrase inhibitors using in silico structure-based combinatorial library design approach
2019-01-01 Sirous, Hajar; Chemi, Giulia; Gemma, Sandra; Butini, Stefania; Debyser, Zeger; Christ, Frauke; Saghaie, Lotfollah; Brogi, Simone; Fassihi, Afshin; Campiani, Giuseppe; Brindisi, Margherita
Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases
2017-01-01 Zaccagnini, Ludovica; Brogi, Simone; Brindisi, Margherita; Gemma, Sandra; Chemi, Giulia; Legname, Giuseppe; Campiani, Giuseppe; Butini, Stefania
Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions
2020-01-01 Frydenvang, Karla; Pickering, Darryl S; Kshirsagar, Giridhar U; Chemi, Giulia; Gemma, Sandra; Sprogøe, Desiree; Kærn, Anne Mette; Brogi, Simone; Campiani, Giuseppe; Butini, Stefania; Kastrup, Jette Sandholm
Novel quinolone-based potent and selective HDAC6 inhibitors: synthesis, molecular modeling studies and biological investigation
2021-01-01 Relitti, N.; Saraswati, A. P.; Chemi, G.; Brindisi, M.; Brogi, S.; Herp, D.; Schmidtkunz, K.; Saccoccia, F.; Ruberti, G.; Ulivieri, C.; Vanni, F.; Sarno, F.; Altucci, L.; Lamponi, S.; Jung, M.; Gemma, S.; Butini, S.; Campiani, G.
Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies
2018-01-01 Brindisi, Margherita; Senger, Johanna; Cavella, Caterina; Grillo, Alessandro; Chemi, Giulia; Gemma, Sandra; Cucinella, Dora Mariagrazia; Lamponi, Stefania; Sarno, Federica; Iside, Concetta; Nebbioso, Angela; Novellino, Ettore; Shaik, Tajith Baba; Romier, Christophe; Herp, Daniel; Jung, Manfred; Butini, Stefania; Campiani, Giuseppe; Altucci, Lucia; Brogi, Simone
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| (S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic Acid (AMPA) and Kainate Receptor Ligands: further exploration of bioisosteric replacements and structural and biological investigation | 1-gen-2018 | Brogi, Simone; Brindisi, Margherita; Butini, Stefania; Kshirsagar, Giridhar U.; Maramai, Samuele; Chemi, Giulia; Gemma, Sandra; Campiani, Giuseppe; Novellino, Ettore; Fiorenzani, Paolo; Pinassi, Jessica; Aloisi, Anna Maria; Gynther, Mikko; Venskutonytė, Raminta; Han, Liwei; Frydenvang, Karla; Kastrup, Jette Sandholm; Pickering, Darryl S. | - | |
| A Jocic-type approach for a practical and scalable synthesis of pyrrolonaphthoxazepine (PNOX)-based potent proapoptotic agents | 1-gen-2018 | Federico, Stefano; Khan, Tuhina; Relitti, Nicola; Chemi, Giulia; Brindisi, Margherita; Brogi, Simone; Novellino, Ettore; Zisterer, Daniela M.; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania | - | |
| A light in the dark: State of the art and perspectives in optogenetics and optopharmacology for restoring vision | 1-gen-2019 | Chemi, G.; Brindisi, M.; Brogi, S.; Relitti, N.; Butini, S.; Gemma, S.; Campiani, G. | - | |
| A repurposing approach for uncovering the anti-tubercular activity of FDA-approved drugs with Potential Multi-Targeting Profiles | 1-gen-2019 | Battah, B.; Chemi, G.; Butini, S.; Campiani, G.; Brogi, S.; Delogu, G.; Gemma, S. | - | |
| Activation of the Wnt pathway by small peptides: rational design, synthesis and biological evaluation | 1-gen-2017 | Brogi, Simone; Maramai, Samuele; Brindisi, Margherita; Chemi, Giulia; Porcari, Valentina; Corallo, Claudio; Gennari, Luigi; Novellino, Ettore; Ramunno, Anna; Butini, Stefania; Campiani, Giuseppe; Gemma, Sandra | - | |
| Antimalarial agents against both sexual and asexual parasites stages: structure-activity relationships and biological studies of the Malaria Box compound 1-[5-(4-bromo-2-chlorophenyl)furan-2-yl]- N -[(piperidin-4-yl)methyl]methanamine (MMV019918) and analogues | 1-gen-2018 | Vallone, Alessandra; D'Alessandro, Sarah; Brogi, Simone; Brindisi, Margherita; Chemi, Giulia; Alfano, Gloria; Lamponi, Stefania; Lee, Soon Goo; Jez, Joseph M.; Koolen, Karin J. M.; Dechering, Koen J.; Saponara, Simona; Fusi, Fabio; Gorelli, Beatrice; Taramelli, Donatella; Parapini, Silvia; Caldelari, Reto; Campiani, Giuseppe; Gemma, Sandra; Butini, Stefania | - | |
| Bridged bicyclic 2,3-dioxabicyclo[3.3.1]nonanes as antiplasmodial agents: Synthesis, structure-activity relationships and studies on their biomimetic reaction with Fe(II) | 1-gen-2019 | D'Alessandro, S.; Alfano, G.; Di Cerbo, L.; Brogi, S.; Chemi, G.; Relitti, N.; Brindisi, M.; Lamponi, S.; Novellino, E.; Campiani, G.; Gemma, S.; Basilico, N.; Taramelli, D.; Baratto, M. C.; Pogni, R.; Butini, S. | - | |
| Cinnamides Target Leishmania amazonensis Arginase Selectively | 1-gen-2020 | da Silva, Edson Roberto; Come, Júlio Abel Alfredo dos Santos Simone; Brogi, Simone; Calderone, Vincenzo; Chemi, Giulia; Campiani, Giuseppe; Oliveira, Trícia Maria Ferrreira de Sousa; Pham, Thanh-Nhat; Pudlo, Marc; Girard, Corine; Maquiaveli, Claudia do Carmo | - | |
| Computational tool for fast in silico evaluation of hERG K+ channel affinity | 1-gen-2017 | Chemi, Giulia; Gemma, Sandra; Campiani, Giuseppe; Brogi, Simone; Butini, Stefania; Brindisi, Margherita | - | |
| Computer-aided drug discovery methodologies for the identification and optimization of bioactive compounds | 1-gen-2020 | Chemi, Giulia | - | |
| Computer-driven development of an in silico tool for finding selective histone deacetylase 1 inhibitors | 1-gen-2020 | Sirous, H.; Campiani, G.; Brogi, S.; Calderone, V.; Chemi, G. | - | |
| Design, synthesis and biological evaluation of 7-substituted 4-phenyl-6H-imidazo[1,5-a]thieno[3,2-f] [1,4]diazepines as safe anxiolytic agents | 1-gen-2020 | Di Capua, Angela; Reale, Annalisa; Paolino, Marco; Chemi, Giulia; Brogi, Simone; Cappelli, Andrea; Giorgi, Gianluca; Grande, Fedora; Di Cesare Mannelli, Lorenzo; Ghelardini, Carla; Matucci, Rosanna; Garofalo, Antonio; Anzini, Maurizio | - | |
| Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems | 1-gen-2019 | Grillo, A.; Chemi, G.; Brogi, S.; Brindisi, M.; Relitti, N.; Fezza, F.; Fazio, D.; Castelletti, L.; Perdona, E.; Wong, A.; Lamponi, S.; Pecorelli, A.; Benedusi, M.; Fantacci, M.; Valoti, M.; Valacchi, G.; Micheli, F.; Novellino, E.; Campiani, G.; Butini, S.; Maccarrone, M.; Gemma, S. | - | |
| First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents | 1-gen-2017 | Brogi, Simone; Ramunno, Anna; Savi, Lida; Chemi, Giulia; Alfano, Gloria; Pecorelli, Alessandra; Pambianchi, Erika; Galatello, Paola; Compagnoni, Giulia; Focher, Federico; Biamonti, Giuseppe; Valacchi, Giuseppe; Butini, Stefania; Gemma, Sandra; Campiani, Giuseppe; Brindisi, Margherita | - | |
| Harnessing the role of HDAC6 in Idiopathic Pulmonary Fibrosis: design, synthesis, structural analysis, and biological evaluation of potent inhibitors | 1-gen-2021 | Campiani, Giuseppe; Cavella, Caterina; Osko, Jeremy D; Brindisi, Margherita; Relitti, Nicola; Brogi, Simone; Saraswati, A Prasanth; Federico, Stefano; Chemi, Giulia; Maramai, Samuele; Carullo, Gabriele; Jaeger, Benedikt; Carleo, Alfonso; Benedetti, Rosaria; Sarno, Federica; Lamponi, Stefania; Rottoli, Paola; Bargagli, Elena; Bertucci, Carlo; Tedesco, Daniele; Herp, Daniel; Senger, Johanna; Ruberti, Giovina; Saccoccia, Fulvio; Saponara, Simona; Gorelli, Beatrice; Valoti, Massimo; Kennedy, Breándan; Sundaramurthi, Husvinee; Butini, Stefania; Jung, Manfred; Roach, Katy M; Altucci, Lucia; Bradding, Peter; Christianson, David W; Gemma, Sandra; Prasse, Antje | - | |
| Identification of novel 3-Hydroxy-pyran-4-one derivatives as potent HIV-1 integrase inhibitors using in silico structure-based combinatorial library design approach | 1-gen-2019 | Sirous, Hajar; Chemi, Giulia; Gemma, Sandra; Butini, Stefania; Debyser, Zeger; Christ, Frauke; Saghaie, Lotfollah; Brogi, Simone; Fassihi, Afshin; Campiani, Giuseppe; Brindisi, Margherita | - | |
| Identification of novel fluorescent probes preventing PrP(Sc) replication in prion diseases | 1-gen-2017 | Zaccagnini, Ludovica; Brogi, Simone; Brindisi, Margherita; Gemma, Sandra; Chemi, Giulia; Legname, Giuseppe; Campiani, Giuseppe; Butini, Stefania | - | |
| Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions | 1-gen-2020 | Frydenvang, Karla; Pickering, Darryl S; Kshirsagar, Giridhar U; Chemi, Giulia; Gemma, Sandra; Sprogøe, Desiree; Kærn, Anne Mette; Brogi, Simone; Campiani, Giuseppe; Butini, Stefania; Kastrup, Jette Sandholm | - | |
| Novel quinolone-based potent and selective HDAC6 inhibitors: synthesis, molecular modeling studies and biological investigation | 1-gen-2021 | Relitti, N.; Saraswati, A. P.; Chemi, G.; Brindisi, M.; Brogi, S.; Herp, D.; Schmidtkunz, K.; Saccoccia, F.; Ruberti, G.; Ulivieri, C.; Vanni, F.; Sarno, F.; Altucci, L.; Lamponi, S.; Jung, M.; Gemma, S.; Butini, S.; Campiani, G. | - | |
| Novel spiroindoline HDAC inhibitors: Synthesis, molecular modelling and biological studies | 1-gen-2018 | Brindisi, Margherita; Senger, Johanna; Cavella, Caterina; Grillo, Alessandro; Chemi, Giulia; Gemma, Sandra; Cucinella, Dora Mariagrazia; Lamponi, Stefania; Sarno, Federica; Iside, Concetta; Nebbioso, Angela; Novellino, Ettore; Shaik, Tajith Baba; Romier, Christophe; Herp, Daniel; Jung, Manfred; Butini, Stefania; Campiani, Giuseppe; Altucci, Lucia; Brogi, Simone | - |