DI PISA, FLAVIO
DI PISA, FLAVIO
2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives
2013-01-01 Ferrari, Stefania; Calò, Samuele; Leone, Rosalida; Luciani, Rosaria; Costantino, Luca; Sammak, Susan; DI PISA, Flavio; Pozzi, Cecilia; Mangani, Stefano; Costi, M. Paola
Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform
2019-01-01 Moraes, Carolina B.; Witt, Gesa; Kuzikov, Maria; Ellinger, Bernhard; Calogeropoulou, Theodora; Prousis, Kyriakos C.; Mangani, Stefano; Di Pisa, Flavio; Landi, Giacomo; Iacono, Lucia Dello; Pozzi, Cecilia; Freitas-Junior, Lucio H.; dos Santos Pascoalino, Bruno; Bertolacini, Claudia P.; Behrens, Birte; Keminer, Oliver; Leu, Jennifer; Wolf, Markus; Reinshagen, Jeanette; Cordeiro-da-Silva, Anabela; Santarem, Nuno; Venturelli, Alberto; Wrigley, Stephen; Karunakaran, Deepa; Kebede, Bethlehem; Pöhner, Ina; Müller, Wolfgang; Panecka-Hofman, Joanna; Wade, Rebecca C.; Fenske, Martina; Clos, Joachim; Alunda, José María; Corral, María Jesús; Uliassi, Elisa; Bolognesi, Maria Laura; Linciano, Pasquale; Quotadamo, Antonio; Ferrari, Stefania; Santucci, Matteo; Borsari, Chiara; Costi, Maria Paola; Gul, Sheraz
Assisted assembly of a (µ3-oxo)-tris(µ2-peroxo)triiron(III) cluster in L-ferritins and its functional significance
2016-01-01 Pozzi, C; Ciambellotti, S; Bernacchioni, C; DI PISA, Flavio; Turano, P; Mangani, Stefano
Assisted assembly of a (µ3-oxo)-tris(µ2-peroxo)triiron(III) cluster in L-ferritins and its functional significance.
2017-01-01 Pozzi, Cecilia; Ciambellotti, Silvia; Bernacchioni, Caterina; DI PISA, Flavio; Turano, Paola; Mangani, Stefano
Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam
2018-01-01 Pozzi, Cecilia; Di Pisa, Flavio; De Luca, Filomena; Benvenuti, Manuela; Docquier, Jean Denis; Mangani, Stefano
Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design
2018-01-01 Di Pisa, Flavio; Pozzi, Cecilia; Benvenuti, Manuela; Docquier, Jean-Denis; De Luca, Filomena; Mangani, Stefano
Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo)Tris[(μ2-peroxo)] triiron(III) cluster
2017-01-01 Pozzi, Cecilia; Ciambellotti, Silvia; Bernacchioni, Caterina; DI PISA, Flavio; Mangani, Stefano; Turano, Paola
Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity
2017-01-01 DI PISA, Flavio; Landi, Giacomo; DELLO IACONO, Lucia; Pozzi, Cecilia; Borsari, Chiara; Ferrari, Stefania; Santucci, Matteo; Santarem, Nuno; Cordeiro Da Silva, Anabela; Moraes, Carolina B.; Alcantara, Laura M.; Fontana, Vanessa; Freitas Junior, Lucio H.; Gul, Sheraz; Kuzikov, Maria; Behrens, Birte; Pöhner, Ina; Wade, Rebecca C.; Costi, Maria Paola; Mangani, Stefano
Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors
2017-01-01 Panecka-Hofman, Joanna; Pöhner, Ina; Spyrakis, Francesca; Zeppelin, Talia; Di Pisa, Flavio; Dello Iacono, Lucia; Bonucci, Alessio; Quotadamo, Antonio; Venturelli, Alberto; Mangani, Stefano; Costi, Maria Paola; Wade, Rebecca C.
Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP+/NADPH and the substrate folic acid
2022-01-01 Dello Iacono, Lucia; Di Pisa, Flavio; Mangani, Stefano
Development of flavonol and flavanone derivatives as anti-trypanosomatidic drugs
2017-01-01 Pozzi, Cecilia; DI PISA, Flavio; Landi, Giacomo; DELLO IACONO, Lucia; Costi, MARIA PAOLA; Wade, Rebecca C.; Gul, Sheraz; Cordeiro-da-Silva, Anabela; Mangani, Stefano
Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H′ ferritin
2019-01-01 Pozzi, Cecilia; Di Pisa, Flavio; Lalli, Daniela; Rosa, Camilla; Turano, Paola; Mangani, Stefano
Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections
2019-01-01 Linciano, Pasquale; Pozzi, Cecilia; Iacono, Lucia Dello; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa; Santarem, Nuno; Baptista, Catarina; Franco, Caio; Moraes, Carolina B; Müller, Wolfgang; Wittig, Ulrike; Luciani, Rosaria; Sesenna, Antony; Quotadamo, Antonio; Ferrari, Stefania; Pöhner, Ina; Cordeiro-da-Silva, Anabela; Mangani, Stefano; Costantino, Luca; Costi, Maria Paola
Evolution to carbapenem-hydrolyzing activity in class D β-lactamases by rational protein design
2014-01-01 Pozzi, Cecilia; DI PISA, Flavio; DE LUCA, Filomena; Benvenuti, Manuela; Rossolini, GIAN MARIA; Docquier, JEAN DENIS; Mangani, Stefano.
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery
2017-01-01 Linciano, Pasquale; Dawson, Alice; Pöhner, Ina; Costa, David M; Sá, Monica S; Cordeiro da silva, Anabela; Luciani, Rosaria; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Gribbon, Philip; Reinshagen, Jeanette; Wolf, Markus; Behrens, Birte; Hannaert, Veronique; Michels, Paul A. M; Nerini, Erika; Pozzi, Cecilia; DI PISA, Flavio; Landi, Giacomo; Santarem, Nuno; Ferrari, Stefania; Saxena, Puneet; Lazzari, Sandra; Cannazza, Giuseppe; Freitas junior, Lucio H; Moraes, Carolina B; Pascoalino, Bruno S; Alcântara, Laura M; Bertolacini, Claudia P; Fontana, Vanessa; Wittig, Ulrike; Müller, Wolfgang; Wade, Rebecca C; Hunter, William N; Mangani, Stefano; Costantino, Luca; Costi, Maria Paola
Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity
2016-01-01 Bernacchioni, Caterina; Pozzi, Cecilia; DI PISA, Flavio; Mangani, Stefano; Turano, Paola
Iron binding to human heavy-chain ferritin
2015-01-01 Pozzi, Cecilia; DI PISA, Flavio; Bernacchioni, Caterina; Ciambellotti, Silvia; Turano, Paola; Mangani, Stefano
Loop electrostatics modulates the intersubunit interactions in ferritin
2014-01-01 Bernacchioni, Caterina; Ghini, Veronica; Pozzi, Cecilia; Di Pisa, Flavio; Theil, Elizabeth C.; Turano, Paola
Multitarget, selective compound design yields potent inhibitors of a Kinetoplastid Pteridine Reductase 1
2022-01-01 Pöhner, Ina; Quotadamo, Antonio; Panecka-Hofman, Joanna; Luciani, Rosaria; Santucci, Matteo; Linciano, Pasquale; Landi, Giacomo; Di Pisa, Flavio; Dello Iacono, Lucia; Pozzi, Cecilia; Mangani, Stefano; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Santarem, Nuno; Cordeiro-da-Silva, Anabela; Costi, Maria P; Venturelli, Alberto; Wade, Rebecca C
Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs
2016-01-01 Borsari, Chiara; Lucian, Rosaria; Pozzi, Cecilia; Poehner, Ina; Henrich, Stefan; Trande, Matteo; Cordeiro Da silva, Anabela; Santarem, Nuno; Baptista, Catarina; Tait, Annalisa; DI PISA, Flavio; DELLO IACONO, Lucia; Landi, Giacomo; Gul, Sheraz; Wolf, Markus; Kuzikov, Maria; Ellinger, Bernhard; Reinshagen, Jeanette; Witt, Gesa; Gribbon, Philip; Kohler, Manfred; Keminer, Oliver; Behrens, Birte; Costantino, Luca; Nevado, Paloma Tejera; Bifeld, Eugenia; Eick, Julia; Clos, Joachim; Torrado, Juan; Jiménez Antón, María D.; Corral, María J.; Alunda, José Ma; Pellati, Federica; Wade, Rebecca C.; Ferrari, Stefania; Mangani, Stefano; Costi, Maria Paola
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| 2'-Deoxyuridine 5'-monophosphate substrate displacement in thymidylate synthase through 6-hydroxy-2H-naphtho[1,8-bc]furan-2-one derivatives | 1-gen-2013 | Ferrari, Stefania; Calò, Samuele; Leone, Rosalida; Luciani, Rosaria; Costantino, Luca; Sammak, Susan; DI PISA, Flavio; Pozzi, Cecilia; Mangani, Stefano; Costi, M. Paola | - | |
| Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform | 1-gen-2019 | Moraes, Carolina B.; Witt, Gesa; Kuzikov, Maria; Ellinger, Bernhard; Calogeropoulou, Theodora; Prousis, Kyriakos C.; Mangani, Stefano; Di Pisa, Flavio; Landi, Giacomo; Iacono, Lucia Dello; Pozzi, Cecilia; Freitas-Junior, Lucio H.; dos Santos Pascoalino, Bruno; Bertolacini, Claudia P.; Behrens, Birte; Keminer, Oliver; Leu, Jennifer; Wolf, Markus; Reinshagen, Jeanette; Cordeiro-da-Silva, Anabela; Santarem, Nuno; Venturelli, Alberto; Wrigley, Stephen; Karunakaran, Deepa; Kebede, Bethlehem; Pöhner, Ina; Müller, Wolfgang; Panecka-Hofman, Joanna; Wade, Rebecca C.; Fenske, Martina; Clos, Joachim; Alunda, José María; Corral, María Jesús; Uliassi, Elisa; Bolognesi, Maria Laura; Linciano, Pasquale; Quotadamo, Antonio; Ferrari, Stefania; Santucci, Matteo; Borsari, Chiara; Costi, Maria Paola; Gul, Sheraz | - | |
| Assisted assembly of a (µ3-oxo)-tris(µ2-peroxo)triiron(III) cluster in L-ferritins and its functional significance | 1-gen-2016 | Pozzi, C; Ciambellotti, S; Bernacchioni, C; DI PISA, Flavio; Turano, P; Mangani, Stefano | - | |
| Assisted assembly of a (µ3-oxo)-tris(µ2-peroxo)triiron(III) cluster in L-ferritins and its functional significance. | 1-gen-2017 | Pozzi, Cecilia; Ciambellotti, Silvia; Bernacchioni, Caterina; DI PISA, Flavio; Turano, Paola; Mangani, Stefano | - | |
| Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam | 1-gen-2018 | Pozzi, Cecilia; Di Pisa, Flavio; De Luca, Filomena; Benvenuti, Manuela; Docquier, Jean Denis; Mangani, Stefano | - | |
| Boric acid and acetate anion binding to subclass B3 metallo-β-lactamase BJP-1 provides clues for mechanism of action and inhibitor design | 1-gen-2018 | Di Pisa, Flavio; Pozzi, Cecilia; Benvenuti, Manuela; Docquier, Jean-Denis; De Luca, Filomena; Mangani, Stefano | - | |
| Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo)Tris[(μ2-peroxo)] triiron(III) cluster | 1-gen-2017 | Pozzi, Cecilia; Ciambellotti, Silvia; Bernacchioni, Caterina; DI PISA, Flavio; Mangani, Stefano; Turano, Paola | - | |
| Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity | 1-gen-2017 | DI PISA, Flavio; Landi, Giacomo; DELLO IACONO, Lucia; Pozzi, Cecilia; Borsari, Chiara; Ferrari, Stefania; Santucci, Matteo; Santarem, Nuno; Cordeiro Da Silva, Anabela; Moraes, Carolina B.; Alcantara, Laura M.; Fontana, Vanessa; Freitas Junior, Lucio H.; Gul, Sheraz; Kuzikov, Maria; Behrens, Birte; Pöhner, Ina; Wade, Rebecca C.; Costi, Maria Paola; Mangani, Stefano | - | |
| Comparative mapping of on-targets and off-targets for the discovery of anti-trypanosomatid folate pathway inhibitors | 1-gen-2017 | Panecka-Hofman, Joanna; Pöhner, Ina; Spyrakis, Francesca; Zeppelin, Talia; Di Pisa, Flavio; Dello Iacono, Lucia; Bonucci, Alessio; Quotadamo, Antonio; Venturelli, Alberto; Mangani, Stefano; Costi, Maria Paola; Wade, Rebecca C. | - | |
| Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP+/NADPH and the substrate folic acid | 1-gen-2022 | Dello Iacono, Lucia; Di Pisa, Flavio; Mangani, Stefano | - | |
| Development of flavonol and flavanone derivatives as anti-trypanosomatidic drugs | 1-gen-2017 | Pozzi, Cecilia; DI PISA, Flavio; Landi, Giacomo; DELLO IACONO, Lucia; Costi, MARIA PAOLA; Wade, Rebecca C.; Gul, Sheraz; Cordeiro-da-Silva, Anabela; Mangani, Stefano | - | |
| Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H′ ferritin | 1-gen-2019 | Pozzi, Cecilia; Di Pisa, Flavio; Lalli, Daniela; Rosa, Camilla; Turano, Paola; Mangani, Stefano | - | |
| Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections | 1-gen-2019 | Linciano, Pasquale; Pozzi, Cecilia; Iacono, Lucia Dello; di Pisa, Flavio; Landi, Giacomo; Bonucci, Alessio; Gul, Sheraz; Kuzikov, Maria; Ellinger, Bernhard; Witt, Gesa; Santarem, Nuno; Baptista, Catarina; Franco, Caio; Moraes, Carolina B; Müller, Wolfgang; Wittig, Ulrike; Luciani, Rosaria; Sesenna, Antony; Quotadamo, Antonio; Ferrari, Stefania; Pöhner, Ina; Cordeiro-da-Silva, Anabela; Mangani, Stefano; Costantino, Luca; Costi, Maria Paola | - | |
| Evolution to carbapenem-hydrolyzing activity in class D β-lactamases by rational protein design | 1-gen-2014 | Pozzi, Cecilia; DI PISA, Flavio; DE LUCA, Filomena; Benvenuti, Manuela; Rossolini, GIAN MARIA; Docquier, JEAN DENIS; Mangani, Stefano. | - | |
| Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery | 1-gen-2017 | Linciano, Pasquale; Dawson, Alice; Pöhner, Ina; Costa, David M; Sá, Monica S; Cordeiro da silva, Anabela; Luciani, Rosaria; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Gribbon, Philip; Reinshagen, Jeanette; Wolf, Markus; Behrens, Birte; Hannaert, Veronique; Michels, Paul A. M; Nerini, Erika; Pozzi, Cecilia; DI PISA, Flavio; Landi, Giacomo; Santarem, Nuno; Ferrari, Stefania; Saxena, Puneet; Lazzari, Sandra; Cannazza, Giuseppe; Freitas junior, Lucio H; Moraes, Carolina B; Pascoalino, Bruno S; Alcântara, Laura M; Bertolacini, Claudia P; Fontana, Vanessa; Wittig, Ulrike; Müller, Wolfgang; Wade, Rebecca C; Hunter, William N; Mangani, Stefano; Costantino, Luca; Costi, Maria Paola | - | |
| Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity | 1-gen-2016 | Bernacchioni, Caterina; Pozzi, Cecilia; DI PISA, Flavio; Mangani, Stefano; Turano, Paola | - | |
| Iron binding to human heavy-chain ferritin | 1-gen-2015 | Pozzi, Cecilia; DI PISA, Flavio; Bernacchioni, Caterina; Ciambellotti, Silvia; Turano, Paola; Mangani, Stefano | - | |
| Loop electrostatics modulates the intersubunit interactions in ferritin | 1-gen-2014 | Bernacchioni, Caterina; Ghini, Veronica; Pozzi, Cecilia; Di Pisa, Flavio; Theil, Elizabeth C.; Turano, Paola | - | |
| Multitarget, selective compound design yields potent inhibitors of a Kinetoplastid Pteridine Reductase 1 | 1-gen-2022 | Pöhner, Ina; Quotadamo, Antonio; Panecka-Hofman, Joanna; Luciani, Rosaria; Santucci, Matteo; Linciano, Pasquale; Landi, Giacomo; Di Pisa, Flavio; Dello Iacono, Lucia; Pozzi, Cecilia; Mangani, Stefano; Gul, Sheraz; Witt, Gesa; Ellinger, Bernhard; Kuzikov, Maria; Santarem, Nuno; Cordeiro-da-Silva, Anabela; Costi, Maria P; Venturelli, Alberto; Wade, Rebecca C | - | |
| Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs | 1-gen-2016 | Borsari, Chiara; Lucian, Rosaria; Pozzi, Cecilia; Poehner, Ina; Henrich, Stefan; Trande, Matteo; Cordeiro Da silva, Anabela; Santarem, Nuno; Baptista, Catarina; Tait, Annalisa; DI PISA, Flavio; DELLO IACONO, Lucia; Landi, Giacomo; Gul, Sheraz; Wolf, Markus; Kuzikov, Maria; Ellinger, Bernhard; Reinshagen, Jeanette; Witt, Gesa; Gribbon, Philip; Kohler, Manfred; Keminer, Oliver; Behrens, Birte; Costantino, Luca; Nevado, Paloma Tejera; Bifeld, Eugenia; Eick, Julia; Clos, Joachim; Torrado, Juan; Jiménez Antón, María D.; Corral, María J.; Alunda, José Ma; Pellati, Federica; Wade, Rebecca C.; Ferrari, Stefania; Mangani, Stefano; Costi, Maria Paola | - |