Sfoglia per Autore
Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation
2021-01-01 Relitti, N.; Saraswati, A. P.; Chemi, G.; Brindisi, M.; Brogi, S.; Herp, D.; Schmidtkunz, K.; Saccoccia, F.; Ruberti, G.; Ulivieri, C.; Vanni, F.; Sarno, F.; Altucci, L.; Lamponi, S.; Jung, M.; Gemma, S.; Butini, S.; Campiani, G.
Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity
2021-01-01 Relitti, N.; Federico, S.; Pozzetti, L.; Butini, S.; Lamponi, S.; Taramelli, D.; D'Alessandro, S.; Martin, R. E.; Shafik, S. H.; Summers, R. L.; Babij, S. K.; Habluetzel, A.; Tapanelli, S.; Caldelari, R.; Gemma, S.; Campiani, G.
A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis
2021-01-01 Vanni, Francesca; Lopresti, Ludovica; Zurli, Vanessa; Kabanova, Anna; Cattaneo, Francesca; Sicuranza, Anna; Gozzetti, Alessandro; Gemma, Sandra; Zisterer, Daniela M; Bocchia, Monica; Campiani, Giuseppe; Baldari, Cosima T; Butini, Stefania; Ulivieri, Cristina
Natural Compounds and Synthetic Drugs to Target FAAH Enzyme
2021-01-01 Butini, S.; Gemma, S.; Campiani, G.
Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors
2021-01-01 Campiani, Giuseppe; Cavella, Caterina; Osko, Jeremy D; Brindisi, Margherita; Relitti, Nicola; Brogi, Simone; Saraswati, A Prasanth; Federico, Stefano; Chemi, Giulia; Maramai, Samuele; Carullo, Gabriele; Jaeger, Benedikt; Carleo, Alfonso; Benedetti, Rosaria; Sarno, Federica; Lamponi, Stefania; Rottoli, Paola; Bargagli, Elena; Bertucci, Carlo; Tedesco, Daniele; Herp, Daniel; Senger, Johanna; Ruberti, Giovina; Saccoccia, Fulvio; Saponara, Simona; Gorelli, Beatrice; Valoti, Massimo; Kennedy, Breándan; Sundaramurthi, Husvinee; Butini, Stefania; Jung, Manfred; Roach, Katy M; Altucci, Lucia; Bradding, Peter; Christianson, David W; Gemma, Sandra; Prasse, Antje
Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents
2021-01-01 Grillo, Alessandro; Fezza, Filomena; Chemi, Giulia; Colangeli, Roberto; Brogi, Simone; Fazio, Domenico; Federico, Stefano; Papa, Alessandro; Relitti, Nicola; Di Maio, Roberto; Giorgi, Gianluca; Lamponi, Stefania; Valoti, Massimo; Gorelli, Beatrice; Saponara, Simona; Benedusi, Mascia; Pecorelli, Alessandra; Minetti, Patrizia; Valacchi, Giuseppe; Butini, Stefania; Campiani, Giuseppe; Gemma, Sandra; Maccarrone, Mauro; Di Giovanni, Giuseppe
Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions
2020-01-01 Frydenvang, Karla; Pickering, Darryl S; Kshirsagar, Giridhar U; Chemi, Giulia; Gemma, Sandra; Sprogøe, Desiree; Kærn, Anne Mette; Brogi, Simone; Campiani, Giuseppe; Butini, Stefania; Kastrup, Jette Sandholm
Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation
2020-01-01 Saraswati, A Prasanth; Relitti, Nicola; Brindisi, Margherita; Osko, Jeremy D; Chemi, Giulia; Federico, Stefano; Grillo, Alessandro; Brogi, Simone; Mccabe, Niamh H; Turkington, Richard C; Ibrahim, Ola; O'Sullivan, Jeffrey; Lamponi, Stefania; Ghanim, Magda; Kelly, Vincent P; Zisterer, Daniela; Amet, Rebecca; Hannon Barroeta, Patricia; Vanni, Francesca; Ulivieri, Cristina; Herp, Daniel; Sarno, Federica; Di Costanzo, Antonella; Saccoccia, Fulvio; Ruberti, Giovina; Jung, Manfred; Altucci, Lucia; Gemma, Sandra; Butini, Stefania; Christianson, David W; Campiani, Giuseppe
Retinitis Pigmentosa and Retinal Degenerations: Deciphering Pathways and Targets for Drug Discovery and Development
2020-01-01 Carullo, G.; Federico, S.; Relitti, N.; Gemma, S.; Butini, S.; Campiani, G.
Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas
2020-01-01 Khan, T.; Relitti, N.; Brindisi, M.; Magnano, S.; Zisterer, D.; Gemma, S.; Butini, S.; Campiani, G.
(+)-(R)- and (−)-(S)-Perhexiline maleate: Enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages
2020-01-01 Guidi, A.; Prasanth Saraswati, A.; Relitti, N.; Gimmelli, R.; Saccoccia, F.; Sirignano, C.; Taglialatela-Scafati, O.; Campiani, G.; Ruberti, G.; Gemma, S.
Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents
2020-01-01 Saccoccia, F.; Brindisi, M.; Gimmelli, R.; Relitti, N.; Guidi, A.; Saraswati, A. P.; Cavella, C.; Brogi, S.; Chemi, G.; Butini, S.; Papoff, G.; Senger, J.; Herp, D.; Jung, M.; Campiani, G.; Gemma, S.; Ruberti, G.
Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials
2020-01-01 Relitti, Nicola; Saraswati, Akella P; Federico, Stefano; Khan, Tuhina; Brindisi, Margherita; Zisterer, Daniela; Brogi, Simone; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe
Modulation of the Innate Immune Response by Targeting Toll-like Receptors: A Perspective on Their Agonists and Antagonists
2020-01-01 Federico, S.; Pozzetti, L.; Papa, A.; Carullo, G.; Gemma, S.; Butini, S.; Campiani, G.; Relitti, N.
Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases
2020-01-01 Brindisi, Margherita; Saraswati, A Prasanth; Brogi, Simone; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe
Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-6
2020-01-01 Vanden Eynde, J. J.; Mangoni, A. A.; Rautio, J.; Leprince, J.; Azuma, Y. T.; Garcia-Sosa, A. T.; Hulme, C.; Jampilek, J.; Karaman, R.; Li, W.; Gomes, P. A. C.; Hadjipavlou-Litina, D.; Capasso, R.; Geronikaki, A.; Cerchia, L.; Sabatier, J. M.; Ragno, R.; Tuccinardi, T.; Trabocchi, A.; Winum, J. Y.; Luque, F. J.; Prokai-Tatrai, K.; Spetea, M.; Gutschow, M.; Kosalec, I.; Guillou, C.; Vasconcelos, M. H.; Kokotos, G.; Rastelli, G.; de Sousa, M. E.; Gemma, S.; Manera, C.; Mangani, S.; Siciliano, C.; Galdiero, S.; Liu, H.; Scott, P. J. H.; de Los Rios, C.; Agrofoglio, L. A.; Collina, S.; Guedes, R. C.; Munoz-Torrero, D.
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors
2019-01-01 Sirous, Hajar; Fassihi, Afshin; Brogi, Simone; Campiani, Giuseppe; Christ, Frauke; Debyser, Zeger; Gemma, Sandra; Butini, Stefania; Chemi, Giulia; Grillo, Alessandro; Zabihollahi, Rezvan; Aghasadeghi, Mohammad R; Saghaie, Lotfollah; Memarian, Hamid R
Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems
2019-01-01 Grillo, A.; Chemi, G.; Brogi, S.; Brindisi, M.; Relitti, N.; Fezza, F.; Fazio, D.; Castelletti, L.; Perdona, E.; Wong, A.; Lamponi, S.; Pecorelli, A.; Benedusi, M.; Fantacci, M.; Valoti, M.; Valacchi, G.; Micheli, F.; Novellino, E.; Campiani, G.; Butini, S.; Maccarrone, M.; Gemma, S.
A repurposing approach for uncovering the anti-tubercular activity of FDA-approved drugs with Potential Multi-Targeting Profiles
2019-01-01 Battah, B.; Chemi, G.; Butini, S.; Campiani, G.; Brogi, S.; Delogu, G.; Gemma, S.
Dietary polyphenols rutin, taxifolin and quercetin related compounds target: Leishmania amazonensis arginase
2019-01-01 Da Silva, E. R.; Brogi, S.; Lucon-Junior, J. F.; Campiani, G.; Gemma, S.; Maquiaveli, C. D. C.
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| Novel quinolone-based potent and selective HDAC6 inhibitors: Synthesis, molecular modeling studies and biological investigation | 1-gen-2021 | Relitti, N.; Saraswati, A. P.; Chemi, G.; Brindisi, M.; Brogi, S.; Herp, D.; Schmidtkunz, K.; Saccoccia, F.; Ruberti, G.; Ulivieri, C.; Vanni, F.; Sarno, F.; Altucci, L.; Lamponi, S.; Jung, M.; Gemma, S.; Butini, S.; Campiani, G. | - | |
| Synthesis and biological evaluation of benzhydryl-based antiplasmodial agents possessing Plasmodium falciparum chloroquine resistance transporter (PfCRT) inhibitory activity | 1-gen-2021 | Relitti, N.; Federico, S.; Pozzetti, L.; Butini, S.; Lamponi, S.; Taramelli, D.; D'Alessandro, S.; Martin, R. E.; Shafik, S. H.; Summers, R. L.; Babij, S. K.; Habluetzel, A.; Tapanelli, S.; Caldelari, R.; Gemma, S.; Campiani, G. | - | |
| A novel class of oxazepine-based anti-cancer agents induces cell death in primary human CLL cells and efficiently reduces tumor growth in Eμ-TCL1 mice through the JNK/STAT4/p66Shc axis | 1-gen-2021 | Vanni, Francesca; Lopresti, Ludovica; Zurli, Vanessa; Kabanova, Anna; Cattaneo, Francesca; Sicuranza, Anna; Gozzetti, Alessandro; Gemma, Sandra; Zisterer, Daniela M; Bocchia, Monica; Campiani, Giuseppe; Baldari, Cosima T; Butini, Stefania; Ulivieri, Cristina | - | |
| Natural Compounds and Synthetic Drugs to Target FAAH Enzyme | 1-gen-2021 | Butini, S.; Gemma, S.; Campiani, G. | - | |
| Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors | 1-gen-2021 | Campiani, Giuseppe; Cavella, Caterina; Osko, Jeremy D; Brindisi, Margherita; Relitti, Nicola; Brogi, Simone; Saraswati, A Prasanth; Federico, Stefano; Chemi, Giulia; Maramai, Samuele; Carullo, Gabriele; Jaeger, Benedikt; Carleo, Alfonso; Benedetti, Rosaria; Sarno, Federica; Lamponi, Stefania; Rottoli, Paola; Bargagli, Elena; Bertucci, Carlo; Tedesco, Daniele; Herp, Daniel; Senger, Johanna; Ruberti, Giovina; Saccoccia, Fulvio; Saponara, Simona; Gorelli, Beatrice; Valoti, Massimo; Kennedy, Breándan; Sundaramurthi, Husvinee; Butini, Stefania; Jung, Manfred; Roach, Katy M; Altucci, Lucia; Bradding, Peter; Christianson, David W; Gemma, Sandra; Prasse, Antje | - | |
| Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents | 1-gen-2021 | Grillo, Alessandro; Fezza, Filomena; Chemi, Giulia; Colangeli, Roberto; Brogi, Simone; Fazio, Domenico; Federico, Stefano; Papa, Alessandro; Relitti, Nicola; Di Maio, Roberto; Giorgi, Gianluca; Lamponi, Stefania; Valoti, Massimo; Gorelli, Beatrice; Saponara, Simona; Benedusi, Mascia; Pecorelli, Alessandra; Minetti, Patrizia; Valacchi, Giuseppe; Butini, Stefania; Campiani, Giuseppe; Gemma, Sandra; Maccarrone, Mauro; Di Giovanni, Giuseppe | - | |
| Ionotropic Glutamate Receptor GluA2 in Complex with Bicyclic Pyrimidinedione-Based Compounds: When Small Compound Modifications Have Distinct Effects on Binding Interactions | 1-gen-2020 | Frydenvang, Karla; Pickering, Darryl S; Kshirsagar, Giridhar U; Chemi, Giulia; Gemma, Sandra; Sprogøe, Desiree; Kærn, Anne Mette; Brogi, Simone; Campiani, Giuseppe; Butini, Stefania; Kastrup, Jette Sandholm | - | |
| Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation | 1-gen-2020 | Saraswati, A Prasanth; Relitti, Nicola; Brindisi, Margherita; Osko, Jeremy D; Chemi, Giulia; Federico, Stefano; Grillo, Alessandro; Brogi, Simone; Mccabe, Niamh H; Turkington, Richard C; Ibrahim, Ola; O'Sullivan, Jeffrey; Lamponi, Stefania; Ghanim, Magda; Kelly, Vincent P; Zisterer, Daniela; Amet, Rebecca; Hannon Barroeta, Patricia; Vanni, Francesca; Ulivieri, Cristina; Herp, Daniel; Sarno, Federica; Di Costanzo, Antonella; Saccoccia, Fulvio; Ruberti, Giovina; Jung, Manfred; Altucci, Lucia; Gemma, Sandra; Butini, Stefania; Christianson, David W; Campiani, Giuseppe | - | |
| Retinitis Pigmentosa and Retinal Degenerations: Deciphering Pathways and Targets for Drug Discovery and Development | 1-gen-2020 | Carullo, G.; Federico, S.; Relitti, N.; Gemma, S.; Butini, S.; Campiani, G. | - | |
| Autophagy modulators for the treatment of oral and esophageal squamous cell carcinomas | 1-gen-2020 | Khan, T.; Relitti, N.; Brindisi, M.; Magnano, S.; Zisterer, D.; Gemma, S.; Butini, S.; Campiani, G. | - | |
| (+)-(R)- and (−)-(S)-Perhexiline maleate: Enantioselective synthesis and functional studies on Schistosoma mansoni larval and adult stages | 1-gen-2020 | Guidi, A.; Prasanth Saraswati, A.; Relitti, N.; Gimmelli, R.; Saccoccia, F.; Sirignano, C.; Taglialatela-Scafati, O.; Campiani, G.; Ruberti, G.; Gemma, S. | - | |
| Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents | 1-gen-2020 | Saccoccia, F.; Brindisi, M.; Gimmelli, R.; Relitti, N.; Guidi, A.; Saraswati, A. P.; Cavella, C.; Brogi, S.; Chemi, G.; Butini, S.; Papoff, G.; Senger, J.; Herp, D.; Jung, M.; Campiani, G.; Gemma, S.; Ruberti, G. | - | |
| Telomerase-based Cancer Therapeutics: A Review on their Clinical Trials | 1-gen-2020 | Relitti, Nicola; Saraswati, Akella P; Federico, Stefano; Khan, Tuhina; Brindisi, Margherita; Zisterer, Daniela; Brogi, Simone; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe | - | |
| Modulation of the Innate Immune Response by Targeting Toll-like Receptors: A Perspective on Their Agonists and Antagonists | 1-gen-2020 | Federico, S.; Pozzetti, L.; Papa, A.; Carullo, G.; Gemma, S.; Butini, S.; Campiani, G.; Relitti, N. | - | |
| Old but Gold: Tracking the New Guise of Histone Deacetylase 6 (HDAC6) Enzyme as a Biomarker and Therapeutic Target in Rare Diseases | 1-gen-2020 | Brindisi, Margherita; Saraswati, A Prasanth; Brogi, Simone; Gemma, Sandra; Butini, Stefania; Campiani, Giuseppe | - | |
| Breakthroughs in medicinal chemistry: New targets and mechanisms, new drugs, new hopes-6 | 1-gen-2020 | Vanden Eynde, J. J.; Mangoni, A. A.; Rautio, J.; Leprince, J.; Azuma, Y. T.; Garcia-Sosa, A. T.; Hulme, C.; Jampilek, J.; Karaman, R.; Li, W.; Gomes, P. A. C.; Hadjipavlou-Litina, D.; Capasso, R.; Geronikaki, A.; Cerchia, L.; Sabatier, J. M.; Ragno, R.; Tuccinardi, T.; Trabocchi, A.; Winum, J. Y.; Luque, F. J.; Prokai-Tatrai, K.; Spetea, M.; Gutschow, M.; Kosalec, I.; Guillou, C.; Vasconcelos, M. H.; Kokotos, G.; Rastelli, G.; de Sousa, M. E.; Gemma, S.; Manera, C.; Mangani, S.; Siciliano, C.; Galdiero, S.; Liu, H.; Scott, P. J. H.; de Los Rios, C.; Agrofoglio, L. A.; Collina, S.; Guedes, R. C.; Munoz-Torrero, D. | - | |
| Synthesis, Molecular Modelling and Biological Studies of 3-hydroxy-pyrane-4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors | 1-gen-2019 | Sirous, Hajar; Fassihi, Afshin; Brogi, Simone; Campiani, Giuseppe; Christ, Frauke; Debyser, Zeger; Gemma, Sandra; Butini, Stefania; Chemi, Giulia; Grillo, Alessandro; Zabihollahi, Rezvan; Aghasadeghi, Mohammad R; Saghaie, Lotfollah; Memarian, Hamid R | - | |
| Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems | 1-gen-2019 | Grillo, A.; Chemi, G.; Brogi, S.; Brindisi, M.; Relitti, N.; Fezza, F.; Fazio, D.; Castelletti, L.; Perdona, E.; Wong, A.; Lamponi, S.; Pecorelli, A.; Benedusi, M.; Fantacci, M.; Valoti, M.; Valacchi, G.; Micheli, F.; Novellino, E.; Campiani, G.; Butini, S.; Maccarrone, M.; Gemma, S. | - | |
| A repurposing approach for uncovering the anti-tubercular activity of FDA-approved drugs with Potential Multi-Targeting Profiles | 1-gen-2019 | Battah, B.; Chemi, G.; Butini, S.; Campiani, G.; Brogi, S.; Delogu, G.; Gemma, S. | - | |
| Dietary polyphenols rutin, taxifolin and quercetin related compounds target: Leishmania amazonensis arginase | 1-gen-2019 | Da Silva, E. R.; Brogi, S.; Lucon-Junior, J. F.; Campiani, G.; Gemma, S.; Maquiaveli, C. D. C. | - |
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