Sfoglia per Autore
CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction.
2014-01-01 Zamperini, Claudio; Dreassi, Elena; Vignaroli, Giulia; Botta, Maurizio; Dragoni, S; Schenone, S; Musumeci, Francesca; Valoti, Massimo; Antiochia, R; Botta, M.
New Pyrazolobenzothiazine Derivatives as Hepatitis C Virus NS5B Polymerase Palm Site I Inhibitors
2014-01-01 Giuseppe, Manfroni; Dinesh, Manvar; Maria, Letizia Barreca; Neerja, Kaushik Basu; Pieter, Leyssen; Jan, Paeshuyse; Rolando, Cannalire; Nunzio, Iraci; Amartya, Basu; Maxim, Chudaev; Zamperini, Claudio; Dreassi, Elena; Stefano, Sabatini; Oriana, Tabarrini; Johan, Neyts; Violetta, Cecchetti
Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma.
2014-01-01 Tintori, Cristina; Fallacara, A. L.; Radi, Marco; Zamperini, Claudio; Dreassi, Elena; Crespan, E.; Maga, G.; Schenone, S.; Musumeci, F.; Brullo, C.; Richters, A.; Gasparrini, F.; Angelucci, A.; Festuccia, C.; Delle Monache, S.; Rauh, D.; Botta, M.
Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors
2013-01-01 Vignaroli, Giulia; Zamperini, Claudio; Dreassi, Elena; Radi, Marco; Angelucci, A.; Sanità, P.; Crespan, Emmanuele; Kissova, M.; Maga, Giovanni; Schenone, S.; Musumeci, F.; Botta, Maurizio
Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant
2013-01-01 Botta, Maurizio; Tintori, Cristina; Musumeci, F.; Brullo, C.; Zamperini, Claudio; Dreassi, Elena; Fallacara, ANNA LUCIA; Vignaroli, Giulia; Crespan, E.; Zanoli, S.; Laurenzana, Ilaria; Filippi, I.; Maga, G.; Schenone, S.; Angelucci, A.; Botta, M.
A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model:from in silico screening to cyclodextrin formulation
2012-01-01 Botta, Maurizio; Evensen, L.; Dreassi, Elena; Zamperini, Claudio; Caporicci, M.; Falchi, Federico; Musumeci, A.; Schenone, S.; Lorens, J. B.; Botta, M.
Synthesis, biological activity, and ADME properties of novel S-DABOs/N-DABOs as HIV reverse transcriptase inhibitors.
2012-01-01 Botta, Maurizio; Pagano, M; Franchi, L; Castagnolo, D; Schenone, S; Casaluce, G; Zamperini, Claudio; Dreassi, Elena; Maga, G; Samuele, A; Gonzalo, E; Clotet, B; Esté, Ja; Botta, M.
Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study
2011-01-01 Radi, Marco; Dreassi, Elena; C., Brullo; E., Crespan; Tintori, Cristina; V., Bernardo; Valoti, Massimo; Zamperini, Claudio; H., Daigl; F., Musumeci; Carraro, Fabio; Naldini, Antonella; Filippi, Irene; G., Maga; S., Schenone; Botta, Maurizio
Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells.
2011-01-01 Botta, Maurizio; Brullo, C.; Crespan, E.; Tintori, Cristina; Musumeci, F.; Biava, M.; Schenone, S.; Dreassi, Elena; Zamperini, Claudio; Maga, G.; Pagano, D.; Angelucci, A.; Bologna, M.; Botta, M.
| Titolo | Data di pubblicazione | Autore(i) | File | Abstract |
|---|---|---|---|---|
| CYP-dependent metabolism of antitumor pyrazolo[3,4-d]pyrimidine derivatives is characterized by an oxidative dechlorination reaction. | 1-gen-2014 | Zamperini, Claudio; Dreassi, Elena; Vignaroli, Giulia; Botta, Maurizio; Dragoni, S; Schenone, S; Musumeci, Francesca; Valoti, Massimo; Antiochia, R; Botta, M. | - | |
| New Pyrazolobenzothiazine Derivatives as Hepatitis C Virus NS5B Polymerase Palm Site I Inhibitors | 1-gen-2014 | Giuseppe, Manfroni; Dinesh, Manvar; Maria, Letizia Barreca; Neerja, Kaushik Basu; Pieter, Leyssen; Jan, Paeshuyse; Rolando, Cannalire; Nunzio, Iraci; Amartya, Basu; Maxim, Chudaev; Zamperini, Claudio; Dreassi, Elena; Stefano, Sabatini; Oriana, Tabarrini; Johan, Neyts; Violetta, Cecchetti | - | |
| Combining X-ray Crystallography and Molecular Modeling toward the Optimization of Pyrazolo[3,4-d]pyrimidines as Potent c-Src Inhibitors Active in Vivo against Neuroblastoma. | 1-gen-2014 | Tintori, Cristina; Fallacara, A. L.; Radi, Marco; Zamperini, Claudio; Dreassi, Elena; Crespan, E.; Maga, G.; Schenone, S.; Musumeci, F.; Brullo, C.; Richters, A.; Gasparrini, F.; Angelucci, A.; Festuccia, C.; Delle Monache, S.; Rauh, D.; Botta, M. | - | |
| Pyrazolo[3,4-d]pyrimidine Prodrugs: Strategic Optimization of the Aqueous Solubility of Dual Src/Abl Inhibitors | 1-gen-2013 | Vignaroli, Giulia; Zamperini, Claudio; Dreassi, Elena; Radi, Marco; Angelucci, A.; Sanità, P.; Crespan, Emmanuele; Kissova, M.; Maga, Giovanni; Schenone, S.; Musumeci, F.; Botta, Maurizio | - | |
| Design, synthesis, and biological evaluation of pyrazolo[3,4-d]pyrimidines active in vivo on the Bcr-Abl T315I mutant | 1-gen-2013 | Botta, Maurizio; Tintori, Cristina; Musumeci, F.; Brullo, C.; Zamperini, Claudio; Dreassi, Elena; Fallacara, ANNA LUCIA; Vignaroli, Giulia; Crespan, E.; Zanoli, S.; Laurenzana, Ilaria; Filippi, I.; Maga, G.; Schenone, S.; Angelucci, A.; Botta, M. | - | |
| A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model:from in silico screening to cyclodextrin formulation | 1-gen-2012 | Botta, Maurizio; Evensen, L.; Dreassi, Elena; Zamperini, Claudio; Caporicci, M.; Falchi, Federico; Musumeci, A.; Schenone, S.; Lorens, J. B.; Botta, M. | - | |
| Synthesis, biological activity, and ADME properties of novel S-DABOs/N-DABOs as HIV reverse transcriptase inhibitors. | 1-gen-2012 | Botta, Maurizio; Pagano, M; Franchi, L; Castagnolo, D; Schenone, S; Casaluce, G; Zamperini, Claudio; Dreassi, Elena; Maga, G; Samuele, A; Gonzalo, E; Clotet, B; Esté, Ja; Botta, M. | - | |
| Design, synthesis, biological activity and ADME properties of pyrazolo[3,4-d]pyrimidines active in hypoxic human leukemia cells: a lead optimization study | 1-gen-2011 | Radi, Marco; Dreassi, Elena; C., Brullo; E., Crespan; Tintori, Cristina; V., Bernardo; Valoti, Massimo; Zamperini, Claudio; H., Daigl; F., Musumeci; Carraro, Fabio; Naldini, Antonella; Filippi, Irene; G., Maga; S., Schenone; Botta, Maurizio | - | |
| Identification of potent c-Src inhibitors strongly affecting the proliferation of human neuroblastoma cells. | 1-gen-2011 | Botta, Maurizio; Brullo, C.; Crespan, E.; Tintori, Cristina; Musumeci, F.; Biava, M.; Schenone, S.; Dreassi, Elena; Zamperini, Claudio; Maga, G.; Pagano, D.; Angelucci, A.; Bologna, M.; Botta, M. | - |
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