Ketoprofen L-lysine salt (KLS), a NSAID, is widely used for its analgesic efficacy and tolerability. L-lysine salification was reported to increase the solubility and the gastric absorption and tolerance of ketoprofen. Since the management of NSAIDs gastrotoxicity still represents a major limitation in prolonged therapies, mainly when gastric lesions are present, this study investigated the gastro-protective activity of L-lysine by using a well-established model of gastric mucosa injury, the ethanol-gastric injury model. Several evidences show that the damaging action of ethanol could be attributed to the increase of ROS, which plays a key role in the increase of lipid peroxidation products, including malonyldialdehyde and 4-hydroxy-2-nonenal. With the aim to unravel the mechanism of L-lysine gastroprotection, cellular MDA levels and 4-HNE protein adducts as markers of lipid peroxidation and a panel of key endogenous gastro-protective proteins were assayed. The data obtained indicate a gastroprotective effect of L-lysine on gastric mucosa integrity.

Cimini, A., Brandolini, L., Gentile, R., Cristiano, L., Menghini, P., Fidoamore, A., et al. (2015). Gastroprotective effects of L-Lysine salification of ketoprofen in ethanol-injured gastric mucosa. JOURNAL OF CELLULAR PHYSIOLOGY, 230(4), 813-820 [10.1002/jcp.24809].

Gastroprotective effects of L-Lysine salification of ketoprofen in ethanol-injured gastric mucosa

GIORDANO, ANTONIO;
2015-01-01

Abstract

Ketoprofen L-lysine salt (KLS), a NSAID, is widely used for its analgesic efficacy and tolerability. L-lysine salification was reported to increase the solubility and the gastric absorption and tolerance of ketoprofen. Since the management of NSAIDs gastrotoxicity still represents a major limitation in prolonged therapies, mainly when gastric lesions are present, this study investigated the gastro-protective activity of L-lysine by using a well-established model of gastric mucosa injury, the ethanol-gastric injury model. Several evidences show that the damaging action of ethanol could be attributed to the increase of ROS, which plays a key role in the increase of lipid peroxidation products, including malonyldialdehyde and 4-hydroxy-2-nonenal. With the aim to unravel the mechanism of L-lysine gastroprotection, cellular MDA levels and 4-HNE protein adducts as markers of lipid peroxidation and a panel of key endogenous gastro-protective proteins were assayed. The data obtained indicate a gastroprotective effect of L-lysine on gastric mucosa integrity.
2015
Cimini, A., Brandolini, L., Gentile, R., Cristiano, L., Menghini, P., Fidoamore, A., et al. (2015). Gastroprotective effects of L-Lysine salification of ketoprofen in ethanol-injured gastric mucosa. JOURNAL OF CELLULAR PHYSIOLOGY, 230(4), 813-820 [10.1002/jcp.24809].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/997487
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