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We evaluated the performance of the molecular lab-on-chip-based VerePLEX Biosystem for detection of multidrug-resistant tuberculosis (MDR-TB), obtaining a diagnostic accuracy of more than 97.8% compared to sequencing and MTBDRplus assay for Mycobacterium tuberculosis complex and rifampin and isoniazid resistance detection on clinical isolates and smear-positive specimens. The speed, user-friendly interface, and versatility make it suitable for routine laboratory use.

Cabibbe, A.M., Miotto, P., Moure, R., Alcaide, F., Feuerriegel, S., Pozzi, G., et al. (2015). Lab-on-Chip-Based Platform for Fast Molecular Diagnosis of Multidrug-Resistant Tuberculosis. JOURNAL OF CLINICAL MICROBIOLOGY, 53(12), 3876-3880 [10.1128/JCM.01824-15].

Lab-on-Chip-Based Platform for Fast Molecular Diagnosis of Multidrug-Resistant Tuberculosis

Pozzi, Gianni;
2015-01-01

Abstract

We evaluated the performance of the molecular lab-on-chip-based VerePLEX Biosystem for detection of multidrug-resistant tuberculosis (MDR-TB), obtaining a diagnostic accuracy of more than 97.8% compared to sequencing and MTBDRplus assay for Mycobacterium tuberculosis complex and rifampin and isoniazid resistance detection on clinical isolates and smear-positive specimens. The speed, user-friendly interface, and versatility make it suitable for routine laboratory use.
2015
JOURNAL OF CLINICAL MICROBIOLOGY
Cabibbe, A.M., Miotto, P., Moure, R., Alcaide, F., Feuerriegel, S., Pozzi, G., et al. (2015). Lab-on-Chip-Based Platform for Fast Molecular Diagnosis of Multidrug-Resistant Tuberculosis. JOURNAL OF CLINICAL MICROBIOLOGY, 53(12), 3876-3880 [10.1128/JCM.01824-15].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/996095