Autoinflammatory and autoimmune disorders are characterized by chronic activation of the immune system, which leads to systemic self-directed inflammation in genetically predisposed individuals. Mutations in inflammasome-related proteins have been associated with autoinflammatory disorders, and the link between inflammasome and autoimmune disorders is becoming increasingly clear. As researchers learn more about these two areas, other disorders that were once thought to be autoimmune are now being considered autoinflammatory, or as having at least an autoinflammatory component. This review depicts the role of interleukin-1 as "Ariadne's thread" on the path through the labyrinth of autoinflammatory and autoimmune disorders and emphasizes the blurred boundary between innate and adaptive immune systems.

Cantarini, L., Lopalco, G., Cattalini, M., Vitale, A., Galeazzi, M., Rigante, D. (2015). Interleukin-1: Ariadne's Thread in Autoinflammatory and Autoimmune Disorders. ISRAEL MEDICAL ASSOCIATION JOURNAL, 17(2), 93-97.

Interleukin-1: Ariadne's Thread in Autoinflammatory and Autoimmune Disorders

CANTARINI, LUCA;Vitale, Antonio;GALEAZZI, MAURO;
2015-01-01

Abstract

Autoinflammatory and autoimmune disorders are characterized by chronic activation of the immune system, which leads to systemic self-directed inflammation in genetically predisposed individuals. Mutations in inflammasome-related proteins have been associated with autoinflammatory disorders, and the link between inflammasome and autoimmune disorders is becoming increasingly clear. As researchers learn more about these two areas, other disorders that were once thought to be autoimmune are now being considered autoinflammatory, or as having at least an autoinflammatory component. This review depicts the role of interleukin-1 as "Ariadne's thread" on the path through the labyrinth of autoinflammatory and autoimmune disorders and emphasizes the blurred boundary between innate and adaptive immune systems.
2015
Cantarini, L., Lopalco, G., Cattalini, M., Vitale, A., Galeazzi, M., Rigante, D. (2015). Interleukin-1: Ariadne's Thread in Autoinflammatory and Autoimmune Disorders. ISRAEL MEDICAL ASSOCIATION JOURNAL, 17(2), 93-97.
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/984642
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo