Telomere length is correlated with cellular ageing and immortalization processes. In some human cancers telomere length measurement has proved to be of diagnostic and prognostic value. Results comparable with the traditional terminal restriction fragment length determination by Southern blotting have been obtained in metaphase and interphase cells in some studies by fluorescence in situ hybridization (FISH) analysis; FISH additionally allows for the quantification of telomeres at the cellular level.

Miracco, C., De Santi, M.M., Schürfeld, K., Santopietro, R., Lalinga, A.V., Fimiani, M., et al. (2002). Quantitative in situ evaluation of telomeres in fluorescence in situ hybridization-processed sections of cutaneous melanocytic lesions and correlation with telomerase activity. BRITISH JOURNAL OF DERMATOLOGY, 146(3), 399-408 [10.1046/j.1365-2133.2002.04600.x].

Quantitative in situ evaluation of telomeres in fluorescence in situ hybridization-processed sections of cutaneous melanocytic lesions and correlation with telomerase activity

Miracco, C.;Fimiani, M.;Biagioli, M.;Luzi, P.;
2002-01-01

Abstract

Telomere length is correlated with cellular ageing and immortalization processes. In some human cancers telomere length measurement has proved to be of diagnostic and prognostic value. Results comparable with the traditional terminal restriction fragment length determination by Southern blotting have been obtained in metaphase and interphase cells in some studies by fluorescence in situ hybridization (FISH) analysis; FISH additionally allows for the quantification of telomeres at the cellular level.
2002
Miracco, C., De Santi, M.M., Schürfeld, K., Santopietro, R., Lalinga, A.V., Fimiani, M., et al. (2002). Quantitative in situ evaluation of telomeres in fluorescence in situ hybridization-processed sections of cutaneous melanocytic lesions and correlation with telomerase activity. BRITISH JOURNAL OF DERMATOLOGY, 146(3), 399-408 [10.1046/j.1365-2133.2002.04600.x].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/982560
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