Some original chimeric structures formed by a hydroxamic acid moiety separated from a steroid nucleus (derived from cholanoic or abietic acids) by a seven atoms linker have been prepared and tested against the 11 HDAC isoforms. The products derived from abietic acid show promising results with a particular activity against Class IIb tubuline deaceyilating HDAC6
Randino, R., Cini, E., Taddei, M., Rodriquez, M. (2014). Steroidal hydroxamic acid derivatives: A structurally novel class of hdac inhibitors. PHARMACOLOGYONLINE, 3, 184-189.
Steroidal hydroxamic acid derivatives: A structurally novel class of hdac inhibitors
CINI, ELENA;TADDEI, MAURIZIO;
2014-01-01
Abstract
Some original chimeric structures formed by a hydroxamic acid moiety separated from a steroid nucleus (derived from cholanoic or abietic acids) by a seven atoms linker have been prepared and tested against the 11 HDAC isoforms. The products derived from abietic acid show promising results with a particular activity against Class IIb tubuline deaceyilating HDAC6
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https://hdl.handle.net/11365/982112
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