Here we report the development of a straightforward synthetic procedure for the preparation of spirocyclic endoperoxides as synthetic analogues of the natural product dihydroplakortin. The peroxides presented here are more potent antiplasmodials than dihydroplakortin itself and we proved for the first time their antimalarial activity in vivo. This journal is © The Royal Society of Chemistry 2015
Brindisi, M., Gemma, S., Kunjir, S.A., DI CERBO, L., Brogi, S., Parapini, S., et al. (2015). Synthetic spirocyclic endoperoxides: new antimalarial scaffolds. MEDCHEMCOMM, 6(2), 357-362 [10.1039/C4MD00454J].
Synthetic spirocyclic endoperoxides: new antimalarial scaffolds
BRINDISI, MARGHERITA;GEMMA, SANDRA;KUNJIR, SANIL ASHOK;DI CERBO, LUISA;LAMPONI, STEFANIA;CAMPIANI, GIUSEPPE;BUTINI, STEFANIA
2015-01-01
Abstract
Here we report the development of a straightforward synthetic procedure for the preparation of spirocyclic endoperoxides as synthetic analogues of the natural product dihydroplakortin. The peroxides presented here are more potent antiplasmodials than dihydroplakortin itself and we proved for the first time their antimalarial activity in vivo. This journal is © The Royal Society of Chemistry 2015
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