Initially identified and further developed as inhibitors of cyclooxygenases, nonsteroidal antiinflammatory drugs (NSAIDs) have been more recently shown to bind to and act as agonists of the peroxisome proliferator-activated receptor family of transcription factors. Here we summarize the current knowledge on the functions of the principal targets of NSAIDs and review their role in T and B lymphocytes, with a focus on the molecular mechanisms underlying the effects of NSAIDs on lymphocyte development, activation, differentiation and death.

Rossi Paccani, S., Boncristiano, M., Baldari, C. (2003). Molecular mechanisms underlying suppression of lymphocyte responses by nonsteroidal antiinflammatory drugs. CELLULAR AND MOLECULAR LIFE SCIENCES, 60(6), 1071-1083 [10.1007/s00018-003-2283-9].

Molecular mechanisms underlying suppression of lymphocyte responses by nonsteroidal antiinflammatory drugs

Baldari, C.
2003-01-01

Abstract

Initially identified and further developed as inhibitors of cyclooxygenases, nonsteroidal antiinflammatory drugs (NSAIDs) have been more recently shown to bind to and act as agonists of the peroxisome proliferator-activated receptor family of transcription factors. Here we summarize the current knowledge on the functions of the principal targets of NSAIDs and review their role in T and B lymphocytes, with a focus on the molecular mechanisms underlying the effects of NSAIDs on lymphocyte development, activation, differentiation and death.
2003
Rossi Paccani, S., Boncristiano, M., Baldari, C. (2003). Molecular mechanisms underlying suppression of lymphocyte responses by nonsteroidal antiinflammatory drugs. CELLULAR AND MOLECULAR LIFE SCIENCES, 60(6), 1071-1083 [10.1007/s00018-003-2283-9].
File in questo prodotto:
File Dimensione Formato  
RossiPaccani2003_MolecularMechanismsUnderlying.pdf

non disponibili

Tipologia: PDF editoriale
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 314.87 kB
Formato Adobe PDF
314.87 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/9736
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo