Initially identified and further developed as inhibitors of cyclooxygenases, nonsteroidal antiinflammatory drugs (NSAIDs) have been more recently shown to bind to and act as agonists of the peroxisome proliferator-activated receptor family of transcription factors. Here we summarize the current knowledge on the functions of the principal targets of NSAIDs and review their role in T and B lymphocytes, with a focus on the molecular mechanisms underlying the effects of NSAIDs on lymphocyte development, activation, differentiation and death.
Rossi Paccani, S., Boncristiano, M., Baldari, C. (2003). Molecular mechanisms underlying suppression of lymphocyte responses by nonsteroidal antiinflammatory drugs. CELLULAR AND MOLECULAR LIFE SCIENCES, 60(6), 1071-1083 [10.1007/s00018-003-2283-9].
Molecular mechanisms underlying suppression of lymphocyte responses by nonsteroidal antiinflammatory drugs
Baldari, C.
2003-01-01
Abstract
Initially identified and further developed as inhibitors of cyclooxygenases, nonsteroidal antiinflammatory drugs (NSAIDs) have been more recently shown to bind to and act as agonists of the peroxisome proliferator-activated receptor family of transcription factors. Here we summarize the current knowledge on the functions of the principal targets of NSAIDs and review their role in T and B lymphocytes, with a focus on the molecular mechanisms underlying the effects of NSAIDs on lymphocyte development, activation, differentiation and death.File | Dimensione | Formato | |
---|---|---|---|
RossiPaccani2003_MolecularMechanismsUnderlying.pdf
non disponibili
Tipologia:
PDF editoriale
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
314.87 kB
Formato
Adobe PDF
|
314.87 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/9736
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo