Amphoteric poly(amido-hydrazine)s (PAHYs) were obtained by hydrogen-transfer polyaddition of hydrazine, 1,2-dimethylhydrazine and 1,1-dimethylhydrazine to 2,2-bisacrylamidoacetic acid. These polymers were studied for biomedical applications, such as degradability in water solution, acid-base properties, and cell toxicity. They degraded rapidly in aqueous media under physiological conditions, their molecular weight was reduced to about one-fourth, that of the original polymer in less than two days. They exhibited a typical polyelectrolyte behavior with isoelectric points between 4 and 5 and are prevailingly anionic in the blood. In preliminary cell toxicity essays they proved to be remarkably biocompatible, comparable in this respect to amphoteric poly(amido-amine)s (PAAs), and much less toxic than poly-L-lysine and polyethylenimine. © 2005 SAGE Publications.
Malgesini, B., Ferruti, P., Manfredi, A., Casolaro, M., Chiellini, F. (2005). Synthesis, acid-base properties and preliminary cell compatibility evaluation of amphoteric poly(amido-hydrazine)s. JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS, 20(4), 377-394 [10.1177/0883911505055373].
Synthesis, acid-base properties and preliminary cell compatibility evaluation of amphoteric poly(amido-hydrazine)s
CASOLARO, MARIO;
2005-01-01
Abstract
Amphoteric poly(amido-hydrazine)s (PAHYs) were obtained by hydrogen-transfer polyaddition of hydrazine, 1,2-dimethylhydrazine and 1,1-dimethylhydrazine to 2,2-bisacrylamidoacetic acid. These polymers were studied for biomedical applications, such as degradability in water solution, acid-base properties, and cell toxicity. They degraded rapidly in aqueous media under physiological conditions, their molecular weight was reduced to about one-fourth, that of the original polymer in less than two days. They exhibited a typical polyelectrolyte behavior with isoelectric points between 4 and 5 and are prevailingly anionic in the blood. In preliminary cell toxicity essays they proved to be remarkably biocompatible, comparable in this respect to amphoteric poly(amido-amine)s (PAAs), and much less toxic than poly-L-lysine and polyethylenimine. © 2005 SAGE Publications.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/9138
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