The synthesis of a series of novel α-amino acids based on the nucleophilic substitution of protected 2-amino-4-bromobutanoic acid (1) is described. Basic, acidic or neutral amino acids can be obtained; chimerical amino acids carrying a coenzyme type structure in the side chain, multifunctional amino acids for the synthesis of cross-linked peptides or dendrimers and conformationally constrained peptides can also be obtained.

Ciapetti, P., Mann, A., Shoenfelder, A., Taddei, M. (1998). Nucleophilic substitution of protected 2-amino-4-butanoic acid. An easy route to exotic amino acids and conformationally constrained peptides. TETRAHEDRON LETTERS, 39(22), 3843-3846 [10.1016/S0040-4039(98)00628-5].

Nucleophilic substitution of protected 2-amino-4-butanoic acid. An easy route to exotic amino acids and conformationally constrained peptides

Taddei, Maurizio
1998-01-01

Abstract

The synthesis of a series of novel α-amino acids based on the nucleophilic substitution of protected 2-amino-4-bromobutanoic acid (1) is described. Basic, acidic or neutral amino acids can be obtained; chimerical amino acids carrying a coenzyme type structure in the side chain, multifunctional amino acids for the synthesis of cross-linked peptides or dendrimers and conformationally constrained peptides can also be obtained.
1998
Ciapetti, P., Mann, A., Shoenfelder, A., Taddei, M. (1998). Nucleophilic substitution of protected 2-amino-4-butanoic acid. An easy route to exotic amino acids and conformationally constrained peptides. TETRAHEDRON LETTERS, 39(22), 3843-3846 [10.1016/S0040-4039(98)00628-5].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/8853
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