The salt formed from 2-chloro-4,6-dimethoxy[1,3,5]triazine and N- methylmorpholine (DMTMM) is an effective coupling agent for solid phase peptide synthesis that can be used as economical alternative to PyBOP. Several oligopeptides were prepared on a Wang type resin using this reagent and the yields and purity of the products were always comparable with those obtained with PyBOP as the coupling agent.

Falchi, A., Giacomelli, G., Porcheddu, A., Taddei, M. (2000). “4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl-morpholinium chloride. A Valuable Alternative to PyBOP for Solid Phase Peptide Synthesis. SYNLETT(2), 275-277 [10.1055/s-2000-6490].

“4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl-morpholinium chloride. A Valuable Alternative to PyBOP for Solid Phase Peptide Synthesis

TADDEI M.
2000-01-01

Abstract

The salt formed from 2-chloro-4,6-dimethoxy[1,3,5]triazine and N- methylmorpholine (DMTMM) is an effective coupling agent for solid phase peptide synthesis that can be used as economical alternative to PyBOP. Several oligopeptides were prepared on a Wang type resin using this reagent and the yields and purity of the products were always comparable with those obtained with PyBOP as the coupling agent.
2000
Falchi, A., Giacomelli, G., Porcheddu, A., Taddei, M. (2000). “4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methyl-morpholinium chloride. A Valuable Alternative to PyBOP for Solid Phase Peptide Synthesis. SYNLETT(2), 275-277 [10.1055/s-2000-6490].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/8842
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