The frequency of blood-retina barrier (BRB) and blood-brain barrier (BBB) alterations was studied in 20 cases of Multiple Sclerosis (MS) (12 relapsing and 8 chronic-progressive). BBB impairment was found in 7 out of 20 patients (35%), 3 of whom had the chronic-progressive form of the disease. Alterations to BRB were found in 9 out 20 cases (45%): 2 out 12 (17%) of the relapsing cases and 7 out 8 of the chronic-progressive cases (87.5%). BBB impairment was found in 3 of the 9 cases (33%) with BRB alterations. Our findings indicate that BRB and BBB alterations do not occur simultaneously. We propose that the higher frequency of BRB alterations in chronic-progressive MS may be a sign of persistent antigenic stimulation.

Annunziata, P., D'Ettorre, M., Menchini, U., Moretti, L., Guazzi, G.C. (1988). Frequency of blood-retina and blood-brain barrier changes in multiple sclerosis. ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 9(4), 345-349 [10.1007/BF02333997].

Frequency of blood-retina and blood-brain barrier changes in multiple sclerosis

ANNUNZIATA, P.;
1988-01-01

Abstract

The frequency of blood-retina barrier (BRB) and blood-brain barrier (BBB) alterations was studied in 20 cases of Multiple Sclerosis (MS) (12 relapsing and 8 chronic-progressive). BBB impairment was found in 7 out of 20 patients (35%), 3 of whom had the chronic-progressive form of the disease. Alterations to BRB were found in 9 out 20 cases (45%): 2 out 12 (17%) of the relapsing cases and 7 out 8 of the chronic-progressive cases (87.5%). BBB impairment was found in 3 of the 9 cases (33%) with BRB alterations. Our findings indicate that BRB and BBB alterations do not occur simultaneously. We propose that the higher frequency of BRB alterations in chronic-progressive MS may be a sign of persistent antigenic stimulation.
1988
Annunziata, P., D'Ettorre, M., Menchini, U., Moretti, L., Guazzi, G.C. (1988). Frequency of blood-retina and blood-brain barrier changes in multiple sclerosis. ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES, 9(4), 345-349 [10.1007/BF02333997].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/8537
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