F2-isoprostanes, prostaglandins F2-like compounds formed by free radical-catalyzed lipid peroxidation, are considered the most reliable markers of oxidative stress [1]. It has been repeatedly suggested that newborns are exposed to conditions of oxidative stress resulting from the change from a low oxygen pressure in utero to a high oxygen pressure at birth [2]. We measured the levels of F2-isoprostanes in plasma of newborns by gas chromatography/tandem mass spectrometry and we found that F2-isoprostanes are significantly higher in term newborns as compared to healthy adults. The greatest values were found in preterm newborns in whom F2-isoprostanes are even higher than in term babies. Moreover, a significant inverse correlation was found between the plasma levels of isoprostanes and the gestational age. A quite normal level of isoprostanes was found in mothers both at the delivery and during pregnancy. Placental total F2-isoprostanes (sum of free plus esterified) were significantly higher in preterm as compared to term deliveries. Whether such a difference accounts for the difference in plasma isoprostanes is under investigation. Plasma non-protein-bound iron is higher in preterm than in term newborns, even if no correlation was found with plasma F2- isoprostanes. Erythrocyte desferrioxamine chelatable iron content (0 time) and release (24 h of aerobic incubation) are higher in newborns than in adults and in preterm than in term newborns, but again no correlation was found with plasma F2-isoprostanes. The marked increase in plasma isoprostanes may suggest the possibility that lipid peroxidation, a major process of oxidative stress, occurs in newborns, and may contribute to the understanding of the so called ‘‘free radical disease of the neonate’’.

Comporti, M., Signorini, C., Leoncini, S., Buonocore, G., Rossi, V., Ciccoli, L. (2004). Plasma F2-isoprostanes are elevated in newborns and inversely correlated to the gestational age. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 71(1), 71-71.

Plasma F2-isoprostanes are elevated in newborns and inversely correlated to the gestational age

COMPORTI, M.;SIGNORINI, C.;LEONCINI, S.;BUONOCORE, G.;CICCOLI, L.
2004-01-01

Abstract

F2-isoprostanes, prostaglandins F2-like compounds formed by free radical-catalyzed lipid peroxidation, are considered the most reliable markers of oxidative stress [1]. It has been repeatedly suggested that newborns are exposed to conditions of oxidative stress resulting from the change from a low oxygen pressure in utero to a high oxygen pressure at birth [2]. We measured the levels of F2-isoprostanes in plasma of newborns by gas chromatography/tandem mass spectrometry and we found that F2-isoprostanes are significantly higher in term newborns as compared to healthy adults. The greatest values were found in preterm newborns in whom F2-isoprostanes are even higher than in term babies. Moreover, a significant inverse correlation was found between the plasma levels of isoprostanes and the gestational age. A quite normal level of isoprostanes was found in mothers both at the delivery and during pregnancy. Placental total F2-isoprostanes (sum of free plus esterified) were significantly higher in preterm as compared to term deliveries. Whether such a difference accounts for the difference in plasma isoprostanes is under investigation. Plasma non-protein-bound iron is higher in preterm than in term newborns, even if no correlation was found with plasma F2- isoprostanes. Erythrocyte desferrioxamine chelatable iron content (0 time) and release (24 h of aerobic incubation) are higher in newborns than in adults and in preterm than in term newborns, but again no correlation was found with plasma F2-isoprostanes. The marked increase in plasma isoprostanes may suggest the possibility that lipid peroxidation, a major process of oxidative stress, occurs in newborns, and may contribute to the understanding of the so called ‘‘free radical disease of the neonate’’.
2004
Comporti, M., Signorini, C., Leoncini, S., Buonocore, G., Rossi, V., Ciccoli, L. (2004). Plasma F2-isoprostanes are elevated in newborns and inversely correlated to the gestational age. PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS, 71(1), 71-71.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/6936
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