A new compound, carbamoyl-pyridoxal 5'-phosphate (C-PLP), was synthetized by condensation of pyridoxal 5'-phosphate (PLP) with KCNO. It may be obtained under certain physiological conditions of pH, temperature and concentration of reagents. Formation and degradation of C-PLP are readily reversible chemical reactions, not involving enzymes, at least in rat tissues. However, different considerations suggest that synthesis and breakdown of C-PLP play a biological role in the cell, providing 'protective synthesis' and a 'variable reservoir' of PLP and KCNO, which can be trapped by other proteins, apoenzymes and metabolites, to regulate many cell metabolic functions.

Terzuoli, L., Pizzichini, M., Pagani, R., Guerranti, R., Ponticelli, F., Leoncini, R., et al. (1997). Biological Role of Carbamoyl pyridoxal 5'-phosphate. CELLULAR AND MOLECULAR LIFE SCIENCES, 320(6), 435-440 [10.1016/S0764-4469(97)81970-1].

Biological Role of Carbamoyl pyridoxal 5'-phosphate

Ponticelli, Fabio;Leoncini, Roberto;
1997-01-01

Abstract

A new compound, carbamoyl-pyridoxal 5'-phosphate (C-PLP), was synthetized by condensation of pyridoxal 5'-phosphate (PLP) with KCNO. It may be obtained under certain physiological conditions of pH, temperature and concentration of reagents. Formation and degradation of C-PLP are readily reversible chemical reactions, not involving enzymes, at least in rat tissues. However, different considerations suggest that synthesis and breakdown of C-PLP play a biological role in the cell, providing 'protective synthesis' and a 'variable reservoir' of PLP and KCNO, which can be trapped by other proteins, apoenzymes and metabolites, to regulate many cell metabolic functions.
1997
Terzuoli, L., Pizzichini, M., Pagani, R., Guerranti, R., Ponticelli, F., Leoncini, R., et al. (1997). Biological Role of Carbamoyl pyridoxal 5'-phosphate. CELLULAR AND MOLECULAR LIFE SCIENCES, 320(6), 435-440 [10.1016/S0764-4469(97)81970-1].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/6833
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo