We propose a new approach for photoprotection. 4-Methylbenzylidene camphor (4-MBC), one of the most widely used UV filters, was encapsulated in microspheres, with a view to overcoming problems (percutaneous absorption, photodegradation, lack of lasting effect) arising with organic sunscreens, and to achieve safe photoprotection. We focused on this filter in the light of the Cosmetics Europe opinion concerning its possible effects on the thyroid gland. Microspheres were prepared by emulsification-solvent evaporation, using different amounts of 4-MBC and characterized for morphology, encapsulation efficiency and particle size. The particles were then mixed in O/W emulsions. The in vitro sun protection factors (SPF), in vitro release and photostability were investigated and compared with emulsions containing the free sunscreen. The new microspheres offer good morphology and loading (up to 40%), and the same photoprotection as the free filter while at the same time protecting it from photodegradation. The systems also give a slower release from the emulsions.

Centini, M., Miraglia, G., Quaranta, V., Buonocore, A., Anselmi, C. (2015). Improving photoprotection: 4-Methylbenzylidene Camphor Microsphres. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 20(7), 782-790 [10.3109/10837450.2014.920359].

Improving photoprotection: 4-Methylbenzylidene Camphor Microsphres

Centini, Marisanna;Miraglia, Giovanna;Quaranta, Valeria;Buonocore, Anna;Anselmi, Cecilia
2015-01-01

Abstract

We propose a new approach for photoprotection. 4-Methylbenzylidene camphor (4-MBC), one of the most widely used UV filters, was encapsulated in microspheres, with a view to overcoming problems (percutaneous absorption, photodegradation, lack of lasting effect) arising with organic sunscreens, and to achieve safe photoprotection. We focused on this filter in the light of the Cosmetics Europe opinion concerning its possible effects on the thyroid gland. Microspheres were prepared by emulsification-solvent evaporation, using different amounts of 4-MBC and characterized for morphology, encapsulation efficiency and particle size. The particles were then mixed in O/W emulsions. The in vitro sun protection factors (SPF), in vitro release and photostability were investigated and compared with emulsions containing the free sunscreen. The new microspheres offer good morphology and loading (up to 40%), and the same photoprotection as the free filter while at the same time protecting it from photodegradation. The systems also give a slower release from the emulsions.
2015
Centini, M., Miraglia, G., Quaranta, V., Buonocore, A., Anselmi, C. (2015). Improving photoprotection: 4-Methylbenzylidene Camphor Microsphres. PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 20(7), 782-790 [10.3109/10837450.2014.920359].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/48906
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo