Aim of this work was to evaluate the influence of the incorporation in microspheres of 4-methylbenzylidene camphor (Parsol 5000) on distribution and permeation through reconstituted epidermis (SKINETHIC, RE). The permeation profiles demonstrated that the incorporation of the sunscreen in the microspheres remarkably reduced the flux through reconstituted epidermis of about 20 times while a greater recovery in the stratum corneum was determined with respect to viable epidermis. Furthermore in vitro release of Parsol 5000 from emulsion trough cellulose acetate membrane gave similar results indicating the important role of the microspheres in the interaction with the skin.
D., M., P., C., S., B., S., T., G., D.L., Centini, M., et al. (2012). Incorporation of sunscreen in microspheres: determination of permeation and distribution on reconstituted epidermis (Skinethic).. In Atti XXII Simposio ADRITELF (pp.123-123).
Incorporation of sunscreen in microspheres: determination of permeation and distribution on reconstituted epidermis (Skinethic).
CENTINI, MARISANNA;ANSELMI, CECILIA
2012-01-01
Abstract
Aim of this work was to evaluate the influence of the incorporation in microspheres of 4-methylbenzylidene camphor (Parsol 5000) on distribution and permeation through reconstituted epidermis (SKINETHIC, RE). The permeation profiles demonstrated that the incorporation of the sunscreen in the microspheres remarkably reduced the flux through reconstituted epidermis of about 20 times while a greater recovery in the stratum corneum was determined with respect to viable epidermis. Furthermore in vitro release of Parsol 5000 from emulsion trough cellulose acetate membrane gave similar results indicating the important role of the microspheres in the interaction with the skin.
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https://hdl.handle.net/11365/48854
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