Collision cross-sections (CCS) of positively singly and multiply charged aggregates of the surfactant sodium bis(2-ethythexyl)sulfosuccinate (AOTNa) in the gas phase have been measured by quadrupole ion mobility time-of-flight mass spectrometry. Calibration of the observed drift times to the CCS of the AOTNa non-covalent aggregates was achieved by collecting, under the same experimental conditions, the drift times of a range of singly and multiply charged polyalanine peptides whose CCS had been obtained by conventional ion mobility spectrometry. Together with an obvious increase of the aggregate cross-section with the aggregation number, it was found that the aggregate cross-section increases with the charge state due to the sodium counterions steric effect and the augmented electrostatic repulsion. This finding is consistent with the result of a previous molecular dynamics study on positively charged AOTNa aggregates in the gas phase showing that, by increasing the charge state, the aggregates become progressively more oblate; implying a rise of their CCS. Moreover, the occurrence at each aggregation number and extra charge of a unique value of cross section points toward aggregates whose conformations do not show discernible shape change in the experiment time scale.

Bongiorno, D., Indelicato, S., Giorgi, G., Scarpella, S., Turco Liveri, V., Ceraulo, L. (2014). Electrospray Ion Mobility Mass Spectrometry of Positively Charged Sodium bis(2-ethylhexyl)sulfosuccinate Aggregates. EUROPEAN JOURNAL OF MASS SPECTROMETRY, 20(2), 169-175 [10.1255/ejms.1261].

Electrospray Ion Mobility Mass Spectrometry of Positively Charged Sodium bis(2-ethylhexyl)sulfosuccinate Aggregates

Giorgi G.;
2014-01-01

Abstract

Collision cross-sections (CCS) of positively singly and multiply charged aggregates of the surfactant sodium bis(2-ethythexyl)sulfosuccinate (AOTNa) in the gas phase have been measured by quadrupole ion mobility time-of-flight mass spectrometry. Calibration of the observed drift times to the CCS of the AOTNa non-covalent aggregates was achieved by collecting, under the same experimental conditions, the drift times of a range of singly and multiply charged polyalanine peptides whose CCS had been obtained by conventional ion mobility spectrometry. Together with an obvious increase of the aggregate cross-section with the aggregation number, it was found that the aggregate cross-section increases with the charge state due to the sodium counterions steric effect and the augmented electrostatic repulsion. This finding is consistent with the result of a previous molecular dynamics study on positively charged AOTNa aggregates in the gas phase showing that, by increasing the charge state, the aggregates become progressively more oblate; implying a rise of their CCS. Moreover, the occurrence at each aggregation number and extra charge of a unique value of cross section points toward aggregates whose conformations do not show discernible shape change in the experiment time scale.
2014
Bongiorno, D., Indelicato, S., Giorgi, G., Scarpella, S., Turco Liveri, V., Ceraulo, L. (2014). Electrospray Ion Mobility Mass Spectrometry of Positively Charged Sodium bis(2-ethylhexyl)sulfosuccinate Aggregates. EUROPEAN JOURNAL OF MASS SPECTROMETRY, 20(2), 169-175 [10.1255/ejms.1261].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/48557
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