In the present work, using Congo Red (CR) birefringence and immunofluorescence, we report for the first time the presence of SAA-amyloidosis in the stenotic aortic valve of an alkaptonuric patient. Light microscopy revealed a co-localization of ochronotic pigment and SAA-amyloid, tissue calcification, lipid oxidation, inflammation, and tissue degeneration.
Millucci, L., Ghezzi, L., Braconi, D., Laschi, M., Geminiani, M., Amato, L., et al. (2014). Secondary amyloidosis in an alkaptonuric aortic valve. INTERNATIONAL JOURNAL OF CARDIOLOGY, 172((1)), e121-e123 [10.1016/j.ijcard.2013.12.117].
Secondary amyloidosis in an alkaptonuric aortic valve.
MILLUCCI, LIA;GHEZZI, LORENZO;BRACONI, DANIELA;LASCHI, MARCELLA;GEMINIANI, MICHELA;AMATO, LOREDANA;ORLANDINI, MAURIZIO;BERNARDINI, GIULIA;SANTUCCI, ANNALISA
2014-01-01
Abstract
In the present work, using Congo Red (CR) birefringence and immunofluorescence, we report for the first time the presence of SAA-amyloidosis in the stenotic aortic valve of an alkaptonuric patient. Light microscopy revealed a co-localization of ochronotic pigment and SAA-amyloid, tissue calcification, lipid oxidation, inflammation, and tissue degeneration.
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https://hdl.handle.net/11365/46271
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