Vasoactive intestinal peptide (VIP) was tested for its capability to protect the intrinsic nerves of guinea-pig urinary bladder from damage due to anoxia/glucopenia and reperfusion. Guinea-pig detrusor strips were mounted for tension recording in small organ baths and the nerves were subjected to electric field stimulation. VIP (0.3 microM) improved significantly the response of strips to electrical field stimulation either during anoxia/glucopenia or thereafter during reperfusion, as compared to untreated tissues. The antioxidant activity of VIP assessed as its capability to scavenge peroxyl radicals during linoleic acid oxidation corresponded to 6.42+/-0.13 pIC(50) M, i.e. close to the concentration proved to protect strips against the anoxic--glucopenic and reperfusion damage.

Pessina, F., Kalfin, R., Sgaragli, G. (2001). Vasoactive intestinal peptide protects guinea-pig detrusor nerves from anoxia/glucopenia injury. EUROPEAN JOURNAL OF PHARMACOLOGY, 423(2-3), 229-233 [10.1016/S0014-2999(01)01108-6].

Vasoactive intestinal peptide protects guinea-pig detrusor nerves from anoxia/glucopenia injury

Pessina, Federica;Sgaragli, G.
2001-01-01

Abstract

Vasoactive intestinal peptide (VIP) was tested for its capability to protect the intrinsic nerves of guinea-pig urinary bladder from damage due to anoxia/glucopenia and reperfusion. Guinea-pig detrusor strips were mounted for tension recording in small organ baths and the nerves were subjected to electric field stimulation. VIP (0.3 microM) improved significantly the response of strips to electrical field stimulation either during anoxia/glucopenia or thereafter during reperfusion, as compared to untreated tissues. The antioxidant activity of VIP assessed as its capability to scavenge peroxyl radicals during linoleic acid oxidation corresponded to 6.42+/-0.13 pIC(50) M, i.e. close to the concentration proved to protect strips against the anoxic--glucopenic and reperfusion damage.
2001
Pessina, F., Kalfin, R., Sgaragli, G. (2001). Vasoactive intestinal peptide protects guinea-pig detrusor nerves from anoxia/glucopenia injury. EUROPEAN JOURNAL OF PHARMACOLOGY, 423(2-3), 229-233 [10.1016/S0014-2999(01)01108-6].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/43471
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