Antibodies against the myelin glycolipid galactosylceramide are widely used to study the distribution and function of this molecule. However, anti-galactosylceramide antibodies are not monospecific and have been shown to recognize epitopes carried not only by other glycolipids, but also by proteins. Using expression cloning we have identified a human kidney cDNA which induces a cell-surface protein recognized by the anti-galactosylceramide monoclonal antibody R-mab. These findings further support the idea that cross-reactive proteins may mediate some of the biological effects of the anti galactosylceramide antibodies.

Sosa, M.A., DE GASPERI, R., Battistini, S., Gorman, M.P., Kolodny, R., Kolodny, E.H. (1996). A human kidney cDNA which induces a cell surface protein epitope recognized by a monoclonal antibody against galactosylceramide. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 227(2), 636-641 [10.1006/bbrc.1996.1557].

A human kidney cDNA which induces a cell surface protein epitope recognized by a monoclonal antibody against galactosylceramide

BATTISTINI, S.;
1996-01-01

Abstract

Antibodies against the myelin glycolipid galactosylceramide are widely used to study the distribution and function of this molecule. However, anti-galactosylceramide antibodies are not monospecific and have been shown to recognize epitopes carried not only by other glycolipids, but also by proteins. Using expression cloning we have identified a human kidney cDNA which induces a cell-surface protein recognized by the anti-galactosylceramide monoclonal antibody R-mab. These findings further support the idea that cross-reactive proteins may mediate some of the biological effects of the anti galactosylceramide antibodies.
1996
Sosa, M.A., DE GASPERI, R., Battistini, S., Gorman, M.P., Kolodny, R., Kolodny, E.H. (1996). A human kidney cDNA which induces a cell surface protein epitope recognized by a monoclonal antibody against galactosylceramide. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 227(2), 636-641 [10.1006/bbrc.1996.1557].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/41364
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