It was recently shown that fragment Lys-Ser-Pro-Val (1,2) is the major site in vivo neurofilament phosforilation. A suitable method for the preparation of this peptide was therefore studied paying particular attention to the purification step. Even thought solubility of this peptide in methyl t-butil ether does not allow the standard purification. It is possible achieve a good separation in a single step by HPLC, after a simple extraction with acidic water. © 1989, Taylor & Francis Group, LLC. All rights reserved.

Rustici, M., Santucci, A., Lozzi, L., Pallini, V., Neri, P. (1989). Single step purification of a synthetic peptide fragment of neurofilaments by preparative high performance liquid-chromatography. JOURNAL OF LIQUID CHROMATOGRAPHY, 12(9), 1579-1588 [10.1080/01483918908049527].

Single step purification of a synthetic peptide fragment of neurofilaments by preparative high performance liquid-chromatography

Santucci A.;Lozzi L.;
1989-01-01

Abstract

It was recently shown that fragment Lys-Ser-Pro-Val (1,2) is the major site in vivo neurofilament phosforilation. A suitable method for the preparation of this peptide was therefore studied paying particular attention to the purification step. Even thought solubility of this peptide in methyl t-butil ether does not allow the standard purification. It is possible achieve a good separation in a single step by HPLC, after a simple extraction with acidic water. © 1989, Taylor & Francis Group, LLC. All rights reserved.
1989
Rustici, M., Santucci, A., Lozzi, L., Pallini, V., Neri, P. (1989). Single step purification of a synthetic peptide fragment of neurofilaments by preparative high performance liquid-chromatography. JOURNAL OF LIQUID CHROMATOGRAPHY, 12(9), 1579-1588 [10.1080/01483918908049527].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/411922