Type 1 diabetes mellitus (T1DM) is a multi-factorial autoimmune disease determined by the interaction of genetic, environmental and immunologic factors. One of the environmental risk factors identified by a series of independent studies is represented by viral infection, with strong evidence showing that viruses can indeed infect pancreatic beta cells with consequent effects ranging from functional damage to cell death. In this chapter we review the data obtained both in man and in experimental animal models in support of the potential participation of viral infections to Type 1 diabetes pathogenesis, with a particular emphasis on virus-triggered islet inflammation, beta-cell dysfunction and autoimmunity.

Galleri, L., Sebastiani, G., Vendrame, F., Grieco, F.A., Spagnuolo, I., Dotta, F. (2012). Viral Infections and diabetes. In Ahmad Shamim I. (a cura di), Diabetes: An Old Disease, a New Insight (pp. 252-271). New York : Springer Science+Business Media [10.1007/978-1-4614-5441-0_20].

Viral Infections and diabetes

Sebastiani G.;Dotta F.
2012-01-01

Abstract

Type 1 diabetes mellitus (T1DM) is a multi-factorial autoimmune disease determined by the interaction of genetic, environmental and immunologic factors. One of the environmental risk factors identified by a series of independent studies is represented by viral infection, with strong evidence showing that viruses can indeed infect pancreatic beta cells with consequent effects ranging from functional damage to cell death. In this chapter we review the data obtained both in man and in experimental animal models in support of the potential participation of viral infections to Type 1 diabetes pathogenesis, with a particular emphasis on virus-triggered islet inflammation, beta-cell dysfunction and autoimmunity.
2012
978-1-4614-5440-3
Galleri, L., Sebastiani, G., Vendrame, F., Grieco, F.A., Spagnuolo, I., Dotta, F. (2012). Viral Infections and diabetes. In Ahmad Shamim I. (a cura di), Diabetes: An Old Disease, a New Insight (pp. 252-271). New York : Springer Science+Business Media [10.1007/978-1-4614-5441-0_20].
File in questo prodotto:
Non ci sono file associati a questo prodotto.

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/40175
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo