Several reports have shown elevated circulating beta-endorphin (beta-EP) levels in patients with polycystic ovarian disease (PCOD). However, it is not yet clear whether these high beta-EP levels are linked to the etiopathogenesis of PCOD or are secondary to the obesity. In the present study we measured beta-EP plasma concentrations in 19 PCOD patients, 10 with normal weight (Group A) and 9 with excessive weight (Group B), and in 18 normally ovulating women, 10 with normal weight (Group C) and 9 with excessive weight (Group D). beta-EP values were similar in the two groups of non-obese patients and controls. beta-EP concentrations were also similar in the two groups of obese patients and controls, and they were significantly higher (p less than 0.05) than in non-obese patients. Our data indicate that in PCOD, elevated beta-EP values are related to obesity, suggesting that they are not linked to the pathogenesis of PCOD.

Nappi, C., Petraglia, F., Cudemo, V., Volpe, A., Facchinetti, F., Genazzani, A.R., et al. (1989). Plasma beta-endorphin levels in obese and non-obese patients with polycystic ovarian disease. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY, 30(2), 151-156 [10.1016/0028-2243(89)90062-2].

Plasma beta-endorphin levels in obese and non-obese patients with polycystic ovarian disease

Petraglia, F.;
1989-01-01

Abstract

Several reports have shown elevated circulating beta-endorphin (beta-EP) levels in patients with polycystic ovarian disease (PCOD). However, it is not yet clear whether these high beta-EP levels are linked to the etiopathogenesis of PCOD or are secondary to the obesity. In the present study we measured beta-EP plasma concentrations in 19 PCOD patients, 10 with normal weight (Group A) and 9 with excessive weight (Group B), and in 18 normally ovulating women, 10 with normal weight (Group C) and 9 with excessive weight (Group D). beta-EP values were similar in the two groups of non-obese patients and controls. beta-EP concentrations were also similar in the two groups of obese patients and controls, and they were significantly higher (p less than 0.05) than in non-obese patients. Our data indicate that in PCOD, elevated beta-EP values are related to obesity, suggesting that they are not linked to the pathogenesis of PCOD.
1989
Nappi, C., Petraglia, F., Cudemo, V., Volpe, A., Facchinetti, F., Genazzani, A.R., et al. (1989). Plasma beta-endorphin levels in obese and non-obese patients with polycystic ovarian disease. EUROPEAN JOURNAL OF OBSTETRICS, GYNECOLOGY, AND REPRODUCTIVE BIOLOGY, 30(2), 151-156 [10.1016/0028-2243(89)90062-2].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/35901
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