The conformational properties of cis-5,8,11,14-eicosatetraenoylethanolamide (anandamide) were analysed by the combined use of NMRexperimental results plus molecular simulations. The structure of anandamide was found to be a predominantly linear with a seven-atom ring of the ethanolamine group having a hydrogen bond which stabilizes the molecule. The vinylic group present has a cis conformation in solution. The terminal chain has a linear conformation and undergoes isotropic fast motion typical of this structure
Bonechi, C., Brizzi, A., Brizzi, V., M., F., Donati, A., Rossi, C. (2001). Conformational Analysis of the N-Arachinylethanolamide (Anandamide) using Nuclear Magnetic Resonance and Theoretical Calculations. MAGNETIC RESONANCE IN CHEMISTRY, 39 (8), 432-437.
Conformational Analysis of the N-Arachinylethanolamide (Anandamide) using Nuclear Magnetic Resonance and Theoretical Calculations
BONECHI, CLAUDIA;BRIZZI, ANTONELLA;BRIZZI, VITTORIO;DONATI, ALESSANDRO;ROSSI, CLAUDIO
2001-01-01
Abstract
The conformational properties of cis-5,8,11,14-eicosatetraenoylethanolamide (anandamide) were analysed by the combined use of NMRexperimental results plus molecular simulations. The structure of anandamide was found to be a predominantly linear with a seven-atom ring of the ethanolamine group having a hydrogen bond which stabilizes the molecule. The vinylic group present has a cis conformation in solution. The terminal chain has a linear conformation and undergoes isotropic fast motion typical of this structure
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https://hdl.handle.net/11365/3575
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