In the past decade the application of molecular biology techniques to the study of the genomic structure and function of human papillomaviruses (HPVs) has produced much new data on the epidemiology and biology of these viruses. The attention of many scientists has been captured by genital HPV mainly because: enormous increase in incidence, the broad spectrum of diseases caused by these viruses, the large asymptomatic population harbouring latent infections and the oncogenic potential of certain HPV types. General epidemiology, 'molecular epidemiology' and experimental data indicate that some HPV types are etiological agents of genital squamous cell carcinoma. HPV16 DNA has been found in more than 80% of in situ and invasive cervical carcinomas and integration of the viral DNA into the hostgenome seems to be a crucial step in HPV induced transformation. The transforming activity of HPV seems to be linked to uncontrolled expression of viral E6/E7 proteins that are able to complex with cell polypeptides (p53 and p105RB) involved in down-regulation of cell division. All this has caused radical revision of the diagnostic criteria to be used for the complete and correct management of HPV infections.

Fimiani, M., Mazzatenta, C., Andreassi, L. (1993). New aspects of genital human papillomavirus infections [Aspetti attuali delle infezioni genitali da papillomavirus umani]. ANNALI ITALIANI DI DERMATOLOGIA CLINICA E SPERIMENTALE, 47(2), 103-117.

New aspects of genital human papillomavirus infections [Aspetti attuali delle infezioni genitali da papillomavirus umani]

Fimiani M.;
1993-01-01

Abstract

In the past decade the application of molecular biology techniques to the study of the genomic structure and function of human papillomaviruses (HPVs) has produced much new data on the epidemiology and biology of these viruses. The attention of many scientists has been captured by genital HPV mainly because: enormous increase in incidence, the broad spectrum of diseases caused by these viruses, the large asymptomatic population harbouring latent infections and the oncogenic potential of certain HPV types. General epidemiology, 'molecular epidemiology' and experimental data indicate that some HPV types are etiological agents of genital squamous cell carcinoma. HPV16 DNA has been found in more than 80% of in situ and invasive cervical carcinomas and integration of the viral DNA into the hostgenome seems to be a crucial step in HPV induced transformation. The transforming activity of HPV seems to be linked to uncontrolled expression of viral E6/E7 proteins that are able to complex with cell polypeptides (p53 and p105RB) involved in down-regulation of cell division. All this has caused radical revision of the diagnostic criteria to be used for the complete and correct management of HPV infections.
1993
Fimiani, M., Mazzatenta, C., Andreassi, L. (1993). New aspects of genital human papillomavirus infections [Aspetti attuali delle infezioni genitali da papillomavirus umani]. ANNALI ITALIANI DI DERMATOLOGIA CLINICA E SPERIMENTALE, 47(2), 103-117.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/33678
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