Sixty‐five unselected cases of gastric cancer have been analysed for EBV DNA by polymerase chain reaction, in situ hybridization and immunohistochemistry for CD21 antigen expression. Four cases were found EBV‐positive by PCR, while ISH yielded positive results in 3 of these cases, demonstrating EBV in the nuclei of cancerous cells. CD21 antigen was expressed in cancerous cells in all 3 ISH‐positive cases. All the EBV‐positive cancers of the present series were poorly to moderately differentiated adenocarcinomas with prominent lymphoid infiltration. These results are discussed also on the basis of the literature. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company

Leoncini, L., Vindigni, C., Megha, T., Funtò, I., Pacenti, L., Musarò, M., et al. (1993). Epstein-Barr virus and gastric cancer: data and unanswered questions. INTERNATIONAL JOURNAL OF CANCER, 53(6), 898-901 [10.1002/ijc.2910530605].

Epstein-Barr virus and gastric cancer: data and unanswered questions

LEONCINI L.;RENIERI A.;
1993-01-01

Abstract

Sixty‐five unselected cases of gastric cancer have been analysed for EBV DNA by polymerase chain reaction, in situ hybridization and immunohistochemistry for CD21 antigen expression. Four cases were found EBV‐positive by PCR, while ISH yielded positive results in 3 of these cases, demonstrating EBV in the nuclei of cancerous cells. CD21 antigen was expressed in cancerous cells in all 3 ISH‐positive cases. All the EBV‐positive cancers of the present series were poorly to moderately differentiated adenocarcinomas with prominent lymphoid infiltration. These results are discussed also on the basis of the literature. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company
1993
Leoncini, L., Vindigni, C., Megha, T., Funtò, I., Pacenti, L., Musarò, M., et al. (1993). Epstein-Barr virus and gastric cancer: data and unanswered questions. INTERNATIONAL JOURNAL OF CANCER, 53(6), 898-901 [10.1002/ijc.2910530605].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/3286