This work provides a comprehensive critical summary of urease spectroscopy, crystallography, inhibitor binding, and site-directed mutagenesis, with special emphasis given to the relationships between the structural Features of the Ni-containing active site and the physico-chemical and biochemical properties of this metallo-enzyme. In addition, the recently determined structure of a complex between urease and a transition state analogue is discussed as it leads to a novel, thought-provoking proposal for the enzyme mechanism. (C) 1999 Elsevier Science S.A. All rights reserved.

S., C., S., B., W. R., R., K. S., W., S., M., Mangani, S. (1999). Structural properties of the nickel ions in urease: novel insights into the catalytic and inhibition mechanisms. COORDINATION CHEMISTRY REVIEWS, 192, 331-355 [10.1016/S0010-8545(99)00093-4].

Structural properties of the nickel ions in urease: novel insights into the catalytic and inhibition mechanisms

MANGANI, STEFANO
1999-01-01

Abstract

This work provides a comprehensive critical summary of urease spectroscopy, crystallography, inhibitor binding, and site-directed mutagenesis, with special emphasis given to the relationships between the structural Features of the Ni-containing active site and the physico-chemical and biochemical properties of this metallo-enzyme. In addition, the recently determined structure of a complex between urease and a transition state analogue is discussed as it leads to a novel, thought-provoking proposal for the enzyme mechanism. (C) 1999 Elsevier Science S.A. All rights reserved.
1999
S., C., S., B., W. R., R., K. S., W., S., M., Mangani, S. (1999). Structural properties of the nickel ions in urease: novel insights into the catalytic and inhibition mechanisms. COORDINATION CHEMISTRY REVIEWS, 192, 331-355 [10.1016/S0010-8545(99)00093-4].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/32318
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