D-Ala2, D-Leu5-enkephalin (DADLE) and dynorphin1-13 (Dyn1-13) inhibited striatal adenylate cyclase activity, both basal and dopamine-stimulated (DA), in rats and guinea pigs. The kappa-agonists bremazocine (BRZ), U-50,488 (trans-3,4-dicloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide), and U-69,593 (5 alpha, 7 alpha 8 beta)-(-)-N-methyl-N-(7-(1-pyrrolidinyl-1-oxaspiro (4.5)dec-8yl) benzeneacetamide inhibited only the basal adenylate cyclase activity, and such an effect was restricted to guinea pig striatum, an area known to contain a high density of kappa-binding sites. Moreover, BRZ was found to antagonize the inhibitory effect of both DADLE and Dyn1-13 in rat striatum.

De Montis, M.G., Devoto, P., Preti, A., Tagliamonte, A. (1987). Differential effect of mu, delta, and kappa opioid agonists on adenylate cyclase activity. JOURNAL OF NEUROSCIENCE RESEARCH, 17(4), 435-439 [10.1002/jnr.490170416].

Differential effect of mu, delta, and kappa opioid agonists on adenylate cyclase activity

De Montis, M. G.;
1987-01-01

Abstract

D-Ala2, D-Leu5-enkephalin (DADLE) and dynorphin1-13 (Dyn1-13) inhibited striatal adenylate cyclase activity, both basal and dopamine-stimulated (DA), in rats and guinea pigs. The kappa-agonists bremazocine (BRZ), U-50,488 (trans-3,4-dicloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]- benzeneacetamide), and U-69,593 (5 alpha, 7 alpha 8 beta)-(-)-N-methyl-N-(7-(1-pyrrolidinyl-1-oxaspiro (4.5)dec-8yl) benzeneacetamide inhibited only the basal adenylate cyclase activity, and such an effect was restricted to guinea pig striatum, an area known to contain a high density of kappa-binding sites. Moreover, BRZ was found to antagonize the inhibitory effect of both DADLE and Dyn1-13 in rat striatum.
1987
De Montis, M.G., Devoto, P., Preti, A., Tagliamonte, A. (1987). Differential effect of mu, delta, and kappa opioid agonists on adenylate cyclase activity. JOURNAL OF NEUROSCIENCE RESEARCH, 17(4), 435-439 [10.1002/jnr.490170416].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/31349
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