[GRAPHICS] beta -Lactams were prepared on solid phase starting from serine, threonine, or other beta -hydroxyacids derived from naturally occurring amino acids and a resin bound hydroxylamine, The ring closure was carried out under mitsunobu conditions. The amino group present on the beta -lactam was used to assemble a short peptide. After a reductive cleavage with SmI2, beta -lactam-containing peptides were obtained.
Meloni, M.M., Taddei, M. (2001). Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach. ORGANIC LETTERS, 3(3), 337-340 [10.1021/ol006779z].
Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach
Taddei, Maurizio
2001-01-01
Abstract
[GRAPHICS] beta -Lactams were prepared on solid phase starting from serine, threonine, or other beta -hydroxyacids derived from naturally occurring amino acids and a resin bound hydroxylamine, The ring closure was carried out under mitsunobu conditions. The amino group present on the beta -lactam was used to assemble a short peptide. After a reductive cleavage with SmI2, beta -lactam-containing peptides were obtained.
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https://hdl.handle.net/11365/30634
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