Several polyhydroxylated pyrrolidines with an aliphatic long chain on the ring nitrogen were prepared starting from D-mannitol. An amphiphilic bis-azasugar scaffold has been also prepared. These products behave as cationic surfactants and show a promising anti HIV-I activity. (C) 1998 Elsevier Science Ltd. All rights reserved.
Esposito, A., Falorni, M., Taddei, M. (1998). Synthesis of amphiphilic polyhydroxylated pyrrolidines as potential glycosidase inhibitors. TETRAHEDRON LETTERS, 39(36), 6543-6546 [10.1016/S0040-4039(98)01361-6].
Synthesis of amphiphilic polyhydroxylated pyrrolidines as potential glycosidase inhibitors
Taddei, Maurizio
1998-01-01
Abstract
Several polyhydroxylated pyrrolidines with an aliphatic long chain on the ring nitrogen were prepared starting from D-mannitol. An amphiphilic bis-azasugar scaffold has been also prepared. These products behave as cationic surfactants and show a promising anti HIV-I activity. (C) 1998 Elsevier Science Ltd. All rights reserved.
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