6-Vinvlcytidine derivative (1) possessing good Michael acceptor properties has been synthesized through C-6 formylation and subsequent Wittig reaction. In view of introducing the reactive nucleoside into the oligonucleotide sequence, protection of the vinyl group as ethylthio derivative was proved to be effective for the masking and subsequent regeneration or the reactive vinyl moiety.
Radi, M., Mugnaini, C., Petricci, E., Corelli, F., Botta, M. (2005). Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides. TETRAHEDRON LETTERS, 46(25), 4361-4364 [10.1016/j.tetlet.2005.04.083].
Synthesis of reactive cytidine derivatives as building blocks for cross-linking oligonucleotides
MUGNAINI, CLAUDIA;PETRICCI, ELENA;CORELLI, FEDERICO;BOTTA, MAURIZIO
2005-01-01
Abstract
6-Vinvlcytidine derivative (1) possessing good Michael acceptor properties has been synthesized through C-6 formylation and subsequent Wittig reaction. In view of introducing the reactive nucleoside into the oligonucleotide sequence, protection of the vinyl group as ethylthio derivative was proved to be effective for the masking and subsequent regeneration or the reactive vinyl moiety.
| File | Dimensione | Formato | |
|---|---|---|---|
|
1-s2.0-S0040403905009068-main.pdf
non disponibili
Tipologia:
PDF editoriale
Licenza:
NON PUBBLICO - Accesso privato/ristretto
Dimensione
127.54 kB
Formato
Adobe PDF
|
127.54 kB | Adobe PDF | Visualizza/Apri Richiedi una copia |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
https://hdl.handle.net/11365/2897
Attenzione
Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo