The title compds. I or II [R = morpholinyl, thiomorpholinyl, N-methylpiperazinyl, N-isopropylpiperazinyl, N-acetylpiperazinyl, piperidinyl or imidazolyl; R1 = H, substituted Ph, 1-naphthyl; R2 = H, Me, Et, iso-Pr, (un)substituted CH2Ph; if the compd. has a general formula I, X = N and Y = N or CH; if the compd. has a general formula II, X = O, S or N and Y = N or CH; with provisos], useful as antitubercular agents having high activity and low toxicity, were prepd. E.g., a multi-step synthesis of III, starting from Me vinyl ketone and p-tolualdehyde, was given. III showed MIC of 0.4 μg/mL toward M. tuberculosis 103471. The invention concerns the use of the described compds. as antitubercular agents and process to obtain intermediates and final compds.

Biava, M., Manetti, F., Deidda, D., Pompei, R., Botta, M., Porretta, G.C. (2006)158. Preparation of analogues of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine as antitubercular agents. . Brevetto No. WO 2006092822.

158. Preparation of analogues of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine as antitubercular agents

MANETTI, FABRIZIO;BOTTA, MAURIZIO;
2006-01-01

Abstract

The title compds. I or II [R = morpholinyl, thiomorpholinyl, N-methylpiperazinyl, N-isopropylpiperazinyl, N-acetylpiperazinyl, piperidinyl or imidazolyl; R1 = H, substituted Ph, 1-naphthyl; R2 = H, Me, Et, iso-Pr, (un)substituted CH2Ph; if the compd. has a general formula I, X = N and Y = N or CH; if the compd. has a general formula II, X = O, S or N and Y = N or CH; with provisos], useful as antitubercular agents having high activity and low toxicity, were prepd. E.g., a multi-step synthesis of III, starting from Me vinyl ketone and p-tolualdehyde, was given. III showed MIC of 0.4 μg/mL toward M. tuberculosis 103471. The invention concerns the use of the described compds. as antitubercular agents and process to obtain intermediates and final compds.
2006
Biava, M., Manetti, F., Deidda, D., Pompei, R., Botta, M., Porretta, G.C. (2006)158. Preparation of analogues of 1-{[1,5-bis(4-chlorophenyl)-2-methyl-1H-pyrrol-3-yl]methyl}-4-methylpiperazine as antitubercular agents. . Brevetto No. WO 2006092822.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/27685
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