An efficient synthetic strategy has been developed to prepare an oxygenated analog of Taxuspine X. Macrocycle formation through Yamaguchi macrolactonization approach gave access to an original compound (18) showing remarkable P-gp modulating activity. Further functionalization of this versatile scaffold could lead to potential anticancer and/or MDR reversing agents.
S. I., A., Galletti, E., Renzulli, M.L., Giorgi, G., Sgaragli, G.P., Alderighi, D., et al. (2008). Synthesis of an original oxygenated taxuspine X analogue: a versatile non-natural natural product with remarkable P-gp modulating activity. CHEMMEDCHEM, 3(5), 745-748 [10.1002/cmdc.200700337].
Synthesis of an original oxygenated taxuspine X analogue: a versatile non-natural natural product with remarkable P-gp modulating activity
GALLETTI, ELENA;RENZULLI, MICHELA LUCIA;GIORGI, GIANLUCA;SGARAGLI, GIAN PIETRO;ALDERIGHI, DANIELA;CORELLI, FEDERICO;BOTTA, MAURIZIO
2008-01-01
Abstract
An efficient synthetic strategy has been developed to prepare an oxygenated analog of Taxuspine X. Macrocycle formation through Yamaguchi macrolactonization approach gave access to an original compound (18) showing remarkable P-gp modulating activity. Further functionalization of this versatile scaffold could lead to potential anticancer and/or MDR reversing agents.
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https://hdl.handle.net/11365/27218
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