The copper complexes [Cu(Pyimpy)(H2O)](ClO4)2 (1), [Cu(Pyimpy)2](ClO4)2 (2), [Cu(Pyimpy)(Cl)2]2H2O (32H2O), [Cu(Pyimpy)(N3)(ClO4)]2 (4) and [Cu(Pyimpy)(SCN)(ClO4)]2 (5) were synthesized and characterized by spectroscopic techniques, crystal structures and electrochemical studies (Pyimpy: (2-((2-phenyl- 2-(pyridin-2-l)hydrazono)methyl)pyridine)). The superoxide scavenging activity of the two water soluble complexes 1 and 3 was examined. DNA interaction studies by UV–Vis absorption spectral changes during a titration experiment indicated the generation of new species. These small molecule SOD mimics exhibited excellent DNA cleavage activity in the presence of H2O2 as well as 2-mercaptoethanol. Complexes 1–5 exhibited better cytotoxicity compared to CuCl22H2O and the ligand Pyimpy, and showed more potency than cisplatin for MCF-7, PC-3 and HEK-293 cells. Complex 3 exhibited the highest potency for MCF-7, PC-3 and HEK-293 cells compared to the other complexes.

Ghosh, K., Kumar, P., Tyagi, N., Singh, U.P., Goel, N., Chakraborty, A., et al. (2011). DNA interaction, superoxide scavenging and cytotoxicity studies on new copper(II) complexes derived from tridentate ligand. POLYHEDRON, 30(16), 2667-2677 [10.1016/j.poly.2011.07.019].

DNA interaction, superoxide scavenging and cytotoxicity studies on new copper(II) complexes derived from tridentate ligand

BARATTO, MARIA CAMILLA
2011-01-01

Abstract

The copper complexes [Cu(Pyimpy)(H2O)](ClO4)2 (1), [Cu(Pyimpy)2](ClO4)2 (2), [Cu(Pyimpy)(Cl)2]2H2O (32H2O), [Cu(Pyimpy)(N3)(ClO4)]2 (4) and [Cu(Pyimpy)(SCN)(ClO4)]2 (5) were synthesized and characterized by spectroscopic techniques, crystal structures and electrochemical studies (Pyimpy: (2-((2-phenyl- 2-(pyridin-2-l)hydrazono)methyl)pyridine)). The superoxide scavenging activity of the two water soluble complexes 1 and 3 was examined. DNA interaction studies by UV–Vis absorption spectral changes during a titration experiment indicated the generation of new species. These small molecule SOD mimics exhibited excellent DNA cleavage activity in the presence of H2O2 as well as 2-mercaptoethanol. Complexes 1–5 exhibited better cytotoxicity compared to CuCl22H2O and the ligand Pyimpy, and showed more potency than cisplatin for MCF-7, PC-3 and HEK-293 cells. Complex 3 exhibited the highest potency for MCF-7, PC-3 and HEK-293 cells compared to the other complexes.
2011
Ghosh, K., Kumar, P., Tyagi, N., Singh, U.P., Goel, N., Chakraborty, A., et al. (2011). DNA interaction, superoxide scavenging and cytotoxicity studies on new copper(II) complexes derived from tridentate ligand. POLYHEDRON, 30(16), 2667-2677 [10.1016/j.poly.2011.07.019].
File in questo prodotto:
File Dimensione Formato  
Polyhedron_2011.pdf

non disponibili

Tipologia: Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 699.97 kB
Formato Adobe PDF
699.97 kB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/22313
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo