The coordinate modulation of the cellular functions of cadherins and integrins plays an essential role in fundamental physiological and pathological processes, including morphogenesis, tissue differentiation and renewal, wound healing, immune surveillance, inflammatory response, tumor progression, and metastasis. However, the molecular mechanisms underlying the fine-tuned functional communication between cadherins and integrins are still elusive. This paper focuses on recent findings towards the involvement of reactive oxygen species (ROS) in the regulation of cell adhesion and signal transduction functions of integrins and cadherins, pointing to ROS as emerging strong candidates for modulating the molecular crosstalk between cell-matrix and cell-cell adhesion receptors.

L., G., B., P., Ferro, E.M.P., Trabalzini, L., S. F., R. (2012). Molecular Crosstalk between Integrins and Cadherins: do Reactive Oxygen Species Set the Talk?. JOURNAL OF SIGNAL TRANSDUCTION (ONLINE) [10.1155/2012/807682].

Molecular Crosstalk between Integrins and Cadherins: do Reactive Oxygen Species Set the Talk?

FERRO, ELISA MARIA PAOLA;TRABALZINI, LORENZA;
2012-01-01

Abstract

The coordinate modulation of the cellular functions of cadherins and integrins plays an essential role in fundamental physiological and pathological processes, including morphogenesis, tissue differentiation and renewal, wound healing, immune surveillance, inflammatory response, tumor progression, and metastasis. However, the molecular mechanisms underlying the fine-tuned functional communication between cadherins and integrins are still elusive. This paper focuses on recent findings towards the involvement of reactive oxygen species (ROS) in the regulation of cell adhesion and signal transduction functions of integrins and cadherins, pointing to ROS as emerging strong candidates for modulating the molecular crosstalk between cell-matrix and cell-cell adhesion receptors.
2012
L., G., B., P., Ferro, E.M.P., Trabalzini, L., S. F., R. (2012). Molecular Crosstalk between Integrins and Cadherins: do Reactive Oxygen Species Set the Talk?. JOURNAL OF SIGNAL TRANSDUCTION (ONLINE) [10.1155/2012/807682].
File in questo prodotto:
File Dimensione Formato  
JST2012-807682.pdf

non disponibili

Tipologia: Post-print
Licenza: NON PUBBLICO - Accesso privato/ristretto
Dimensione 1.02 MB
Formato Adobe PDF
1.02 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11365/21677
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo